Show simple item record

dc.contributor.authorKentgens, Anne-Christianneen
dc.contributor.authorGuidi, Marisaen
dc.contributor.authorKorten, Insaen
dc.contributor.authorKohler, Lenaen
dc.contributor.authorBinggeli, Severinen
dc.contributor.authorSinger, Florianen
dc.contributor.authorLatzin, Philippen
dc.contributor.authorAnagnostopoulou, Pinelopien
dc.creatorKentgens, Anne-Christianneen
dc.creatorGuidi, Marisaen
dc.creatorKorten, Insaen
dc.creatorKohler, Lenaen
dc.creatorBinggeli, Severinen
dc.creatorSinger, Florianen
dc.creatorLatzin, Philippen
dc.creatorAnagnostopoulou, Pinelopien
dc.description.abstractINTRODUCTION: Multiple breath washout (MBW) is a sensitive test to measure lung volumes and ventilation inhomogeneity from infancy on. The commonly used setup for infant MBW, based on ultrasonic flowmeter, requires extensive signal processing, which may reduce robustness. A new setup may overcome some previous limitations but formal validation is lacking. AIM: We assessed the feasibility of infant MBW testing with the new setup and compared functional residual capacity (FRC) values of the old and the new setup in vivo and in vitro. METHODS: We performed MBW in four healthy infants and four infants with cystic fibrosis, as well as in a Plexiglas lung simulator using realistic lung volumes and breathing patterns, with the new (Exhalyzer D, Spiroware 3.2.0, Ecomedics) and the old setup (Exhalyzer D, WBreath 3.18.0, ndd) in random sequence. RESULTS: The technical feasibility of MBW with the new device-setup was 100%. Intra-subject variability in FRC was low in both setups, but differences in FRC between the setups were considerable (mean relative difference 39.7%, range 18.9en
dc.description.abstract65.7, P = 0.008). Corrections of software settings decreased FRC differences (14.0%, -6.4en
dc.description.abstract42.3, P = 0.08). Results were confirmed in vitro. CONCLUSION: MBW measurements with the new setup were feasible in infants. However, despite attempts to correct software settings, outcomes between setups were not interchangeable. Further work is needed before widespread application of the new setup can be recommended.en
dc.sourcePediatric Pulmonologyen
dc.titleInfant multiple breath washout using a new commercially available device: Ready to replace the previous setup?en
dc.description.endingpage635Ιατρική Σχολή / Medical SchoolΙατρική Σχολή / Medical School
dc.source.abbreviationPediatr. Pulmonol.en
dc.contributor.orcidAnagnostopoulou, Pinelopi [0000-0003-2597-8016]
dc.contributor.orcidLatzin, Philipp [0000-0002-5239-1571]
dc.contributor.orcidSinger, Florian [0000-0003-3471-5664]

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record