Synthetic libraries of tyrosine-derived bacterial metabolites

Georgiades, Savvas N.; Clardy, J.

doi:10.1016/j.bmcl.2007.10.058

dc.contributor.author	Georgiades, Savvas N.	en
dc.contributor.author	Clardy, J.	en
dc.creator	Georgiades, Savvas N.	en
dc.creator	Clardy, J.	en
dc.date.accessioned	2019-11-21T06:19:05Z
dc.date.available	2019-11-21T06:19:05Z
dc.date.issued	2008
dc.identifier.issn	0960-894X
dc.identifier.uri	http://gnosis.library.ucy.ac.cy/handle/7/55492
dc.description.abstract	The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in Escherichia coli, is reported. The synthetic libraries of N-acyl tyrosines and their 3-keto counterparts were prepared via solid-phase routes, whereas the enamides and enol esters were synthesized in solution-phase. © 2007 Elsevier Ltd. All rights reserved.	en
dc.source	Bioorganic and Medicinal Chemistry Letters	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-43549089738&doi=10.1016%2fj.bmcl.2007.10.058&partnerID=40&md5=fc01bf1008af55dc2742bab1eb4fba4c
dc.subject	article	en
dc.subject	bacterial DNA	en
dc.subject	nonhuman	en
dc.subject	Antibiotics	en
dc.subject	Escherichia coli	en
dc.subject	synthesis	en
dc.subject	Esters	en
dc.subject	structure analysis	en
dc.subject	chemical structure	en
dc.subject	chemical reaction	en
dc.subject	reaction analysis	en
dc.subject	solid	en
dc.subject	Molecular Structure	en
dc.subject	Bacteria (microorganisms)	en
dc.subject	metabolite	en
dc.subject	Tyrosine	en
dc.subject	Amides	en
dc.subject	ester	en
dc.subject	Acyl Meldrum's acids	en
dc.subject	Alcohols	en
dc.subject	Alkenes	en
dc.subject	bacterial metabolism	en
dc.subject	Bacterial metabolites	en
dc.subject	Enamides	en
dc.subject	Enol esters	en
dc.subject	Environmental DNA	en
dc.subject	Libraries	en
dc.subject	Long chain acids	en
dc.subject	Microwave-assisted reactions	en
dc.subject	N-Acyl amino acids	en
dc.subject	Small Molecule Libraries	en
dc.subject	Solid-phase synthesis	en
dc.title	Synthetic libraries of tyrosine-derived bacterial metabolites	en
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	10.1016/j.bmcl.2007.10.058
dc.description.volume	18
dc.description.issue	10
dc.description.startingpage	3117
dc.description.endingpage	3121
dc.author.faculty	002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.department	Τμήμα Χημείας / Department of Chemistry
dc.type.uhtype	Article	en
dc.source.abbreviation	Bioorg.Med.Chem.Lett.	en
dc.contributor.orcid	Georgiades, Savvas N. [0000-0002-6106-9904]
dc.gnosis.orcid	0000-0002-6106-9904

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