Block Methacrylic Polyampholytes as Protein Displacers in Ion‐Exchange Chromatography
Date
1995ISSN
8756-7938Source
Biotechnology progressVolume
11Issue
1Pages
33-38Google Scholar check
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Low molecular weight methacrylic triblock copolymers bearing a block of negatively charged (adsorbing) residues, a sequence of positively charged (repelling) units, and a middle neutral hydrophobic block were utilized successfully in anion‐exchange displacement chromatography for the resolution of a crude mixture of/β‐lactoglobulins into the A and B isoforms. Owing to their low molecular mass and ampholytic nature, these novel displacers possess the attractive process‐scale features of easy column regeneration and polymer recycling. Copyright © 1995 American Institute of Chemical Engineers (AIChE)