Addition of tetraethylthiuram disulfide to antimony(III) iodide
Synthesis, characterization and biological activity
Date
2016Author
Urgut, O. S.Ozturk, I. I.
Banti, Christina N.
Kourkoumelis, Nikolaos
Manoli, Maria
Tasiopoulos, Anastasios J.
Hadjikakou, Sotiris K.
Source
Inorganica Chimica ActaVolume
443Pages
141-150Google Scholar check
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Three new antimony(III) iodide complexes with the N,N-diethylcarbamodithioic acid of formulae {[(SbI(Et2DTC)2)(I2)]n} (1), {[(Sb(Et2DTC)2)4 (SbI6) (I3)]n} (2) and {[SbI(Et2DTC)2]2} (3), (Et2DTCH: N,N-diethylcarbamodithioic acid, C5H11NS2) were synthesized from the reaction of antimony(III) iodide with tetraethylthiuram disulfide in 1:1 stoichiometry. The complexes 1-3 were characterized by melting point, elemental analysis, FT-IR spectroscopy, Raman spectroscopy, 1H, 13C NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Moreover, crystal structures of complexes 1-3 were determinated with single crystal X-ray diffraction analysis. Complexes 1-3 derived from ligand reduction with concomitant degradation of the tetraethylthiuram disulfide to dithiocarbamates. Complexes 1 and 2 are polymer but complex 3 is dimmer. Complex 1 consists of two residues, [SbI(Et2DTC)2] and [I2], while 2 consists of three residues, four cationic [Sb(Et2dtc)2]+, one [SbI6]3- and one [I3]- counter anion. Complexes 1-3 were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervix adenocarcinoma (HeLa) cells. Structure Activity Relationship (SAR) studies reveal that the high activity of the complexes is positively correlated with the low H-all atoms intermolecular contacts. © 2016 Published by Elsevier B.V.