Paraneoplastic Inflammatory Arthritis
Date
2018Author
Rast, FawadParperis, Konstantinos
Amar, Surabhi
Al-Charakh, Mohammed
F, Rast
K, Parperis
S, Amar
M, Al-Charakh
Source
Cureus Journal of Medical ScienceVolume
10Issue
5Google Scholar check
Metadata
Show full item recordAbstract
The immunodeficiency virus infection is known to increase the risk of malignancies, including lymphomas. We report a case of a 51-year-old male with a history of human immunodeficiency virus (HIV) infection, well-controlled on antiretroviral treatment, who presented with polyarthritis and hypercalcemia due to an elevated parathyroid-hormone-related peptide. Computer tomography (CT) revealed diffuse lymphadenopathy and a lymph node biopsy revealed large B-cell lymphoma. He was treated and responded well to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy regimen. Our case highlights the importance of recognizing inflammatory arthritis as an initial manifestation of occult malignancy like large B-cell lymphoma, as the arthritis preceded his eventual diagnosis of lymphoma by several months.