Browsing by Subject "Human immunodeficiency virus 1"

Now showing items 21-40 of 51

    • Article  

      Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype 

      Martinson, J. J.; Hong, L.; Karanicolas, R.; Moore, J. P.; Kostrikis, Leontios G. (2000)
      Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. The CCR2-641 genetic variant [a G to A substitution resulting in a valine (V) to ...
    • Article  

      Global genetic variation of HIV-1 infection 

      Anastassopoulou, C. G.; Kostrikis, Leontios G. (2006)
      Variability, both at the population (interhost) as well as at the individual (intrahost) level is a key property of HIV that stems mainly from the inherent infidelity of the reverse transcriptase enzyme that the virus uses ...
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      HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals 

      Nikolopoulos, Georgios K.; Paraskeva, D.; Psichogiou, M.; Hatzakis, A. (2016)
      The coinfection of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface antigen ...
    • Article  

      HIV epidemiology in Greece 

      Nikolopoulos, Georgios K.; Paraskeva, D.; Hatzakis, A. (2008)
      Greece has experienced early the effect of HIV/AIDS on morbidity and mortality. The era of highly active antiretroviral therapy has alleviated many of the consequences of the epidemic, however, HIV infection remains an ...
    • Article  

      HIV-1 integrase: From biology to chemotherapeutics 

      Zeinalipour-Loizidou, E.; Nicolaou, Charalambos P.; Nicolaïdes, Andrew N.; Kostrikis, Leontios G. (2007)
      AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of ...
    • Article  

      HIV-1 integrase: From biology to chemotherapeuticsAAA 

      Zeinalipour-Loizidou, E.; Nicolaou, Charalambos P.; Nicolaïdes, Andrew N.; Kostrikis, Leontios G. (2007)
      AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of ...
    • Article  

      HIV-1 outbreak among injecting drug users in Greece, 2011: A preliminary report 

      Paraskeva, D.; Nikolopoulos, Georgios K.; Tsiara, Chrissa G.; Paraskeva, D.; Antoniadou, Anastasia; Lazanas, Marios; Gargalianos, Panagiotis; Psychogiou, M.; Malliori-Minerva, Melpomeni; Kremastinou, Jenny; Hatzakis, A. (2011)
      A significant increase (more than 10-fold) in the number of newly diagnosed HIV-1 infections among injecting drug users (IDUs) was observed in Greece during the first seven months of 2011. Molecular epidemiology results ...
    • Article  

      HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics 

      Abecasis, A. B.; Wensing, A. M. J.; Paraskevis, Dimitrios N.; Vercauteren, J.; Theys, K.; Van de Vijver, D. A. M. C.; Albert, Jan; Åsjö, Birgitta; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; De Gascun, C.; Griskevicius, A.; Grossman, Z.; Hamouda, O.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Kücherer, C.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Schmit, J. -C; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Struck, D.; Boucher, C. A. B.; Vandamme, A. -M (2013)
      Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, ...
    • Article  

      HIV-1 vaccine strategies utilizing viral vectors including antigen-displayed inoviral vectors 

      Hassapis, K. A.; Kostrikis, Leontios G. (2013)
      Antigen-presenting viral vectors have been extensively used as vehicles for the presentation of antigens to the immune system in numerous vaccine strategies. Particularly in HIV vaccine development efforts, two main viral ...
    • Article  

      HIV/AIDS: Recent advances in antiretroviral agents 

      Nikolopoulos, Georgios K.; Bonovas, Stefanos; Tsantes, Argirio E.; Sitaras, N. M. (2009)
      Despite the considerable progress in antiretroviral therapy, the eradication of HIV-1 remains unfeasible. Therefore, novel agents are under investigation. The aim of this review is to summarize the conventional compounds, ...
    • Article  

      Impact of HIV type 1 DNA levels on spontaneous disease progression: A meta-analysis 

      Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Goujard, Cecile; Katzenstein, Terese L.; Minga, Albert K.; Rouzioux, C.; Hatzakis, A. (2012)
      Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 ...
    • Article  

      The impact of human allelic variation on HIV-1 disease. 

      Anastassopoulou, C. G.; Kostrikis, Leontios G. (2003)
      Human allelic variants influence the susceptibility to HIV-1 infection and/or the subsequent rates of disease progression towards AIDS that average ten years, although they vary greatly among infected subjects. In this ...
    • Article  

      Impact of natural chemokine receptor polymorphisms on perinatal transmission of human immunodeficiency virus type 1 

      Kostrikis, Leontios G. (2000)
    • Article  

      Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance: Genetic and structural in silico analyses 

      Loizidou, Eriketi Z.; Kousiappa, Ioanna; Zeinalipour-Yazdi, Constantinos D.; Van De Vijver, D. A. M. C.; Kostrikis, Leontios G. (2009)
      The extensive polymorphisms among HIV-1 subtypes have been implicated in drug resistance development. Integrase inhibitors represent the latest addition to the treatment of HIV-1, and their efficacy and resistance patterns ...
    • Article  

      Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance: Genetic and structural in silico analyses 

      Loizidou, Eriketi Z.; Kousiappa, Ioanna; Zeinalipour-Yazdi, Constantinos D.; Van De Vijver, D. A. M. C.; Kostrikis, Leontios G. (2009)
      The extensive polymorphisms among HIV-1 subtypes have been implicated in drug resistance development. Integrase inhibitors represent the latest addition to the treatment of HIV-1, and their efficacy and resistance patterns ...
    • Article  

      Limited cross-border infections in patients newly diagnosed with HIV in Europe 

      Moutschen, M.; Frentz, D.; Wensing, A. M. J.; Albert, Jan; Paraskevis, Dimitrios N.; Abecasis, A. B.; Hamouda, O.; Jørgensen, L. B.; Kücherer, C.; Struck, D.; Schmit, J. -C; Åsjö, Birgitta; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; Coughlan, S.; De Wit, S.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Vandamme, A. -M; Boucher, C. A. B.; Van de Vijver, D. A. M. C.; Balluch, G.; Vandamme, A. -M; Vercauteren, J.; Derdelinckx, I.; Sasse, A.; Bogaert, M.; Ceunen, H.; De Roo, A.; De Wit, S.; Echahidi, F.; Fransen, K.; Goffard, J. -C; Goubau, P.; Goudeseune, E.; Yombi, J. -C; Lacor, P.; Liesnard, C.; Pierard, D.; Rens, R.; Schrooten, Y.; Vaira, D.; Vandekerckhove, L. P. R.; Van den Heuvel, A.; Van Der Gucht, B.; Van Ranst, M.; Van Wijngaerden, E.; Vandercam, B.; Vekemans, M.; Verhofstede, C.; Clumeck, N.; Van Laethem, K.; Demetriades, Ioannis; Kousiappa, Ioanna; Demetriou, Victoria L.; Hezka, Johana; Bruckova, M.; Linka, M.; Machala, L.; Nielsen, C.; Jørgensen, L. B.; Gerstoft, J.; Mathiesen, L.; Pedersen, C.; Nielsen, H.; Laursen, A.; Kvinesdal, B.; Salminen, M.; Ristola, M.; Liitsola, K.; Suni, J.; Sutinen, J.; Korn, K.; Kücherer, C.; Berg, T.; Braun, P.; Poggensee, G.; Däumer, M.; Eberle, J.; Hamouda, O.; Heiken, H.; Kaiser, R.; Knechten, H.; Müller, H.; Neifer, S.; Schmidt, B.; Walter, H.; Gunsenheimer-Bartmeyer, B.; Harrer, T.; Paraskevis, Dimitrios N.; Hatzakis, Angelos E.; Magiorkinis, Emmanouil N.; Hatzitheodorou, Eleni; Haida, Catherine; Zavitsanou, Assimina; Magiorkinis, Gkikas; Lazanas, Marios C.; Chini, Maria C.; Magafas, N.; Tsogas, Nickolaos; Paparizos, Vassilios A.; Kourkounti, Sofia; Antoniadou, Anastasia C.; Papadopoulos, Antonios I.; Panagopoulos, Periklis; Poulakou, Garyphallia G.; Sakka, V.; Chryssos, Georgios; Drimis, Stylianos; Gargalianos, Panagiotis; Lelekis, Moyssis I.; Chilomenos, G.; Psichogiou, Mina A.; Daikos, George L.; Panos, George; Haratsis, G.; Kordossis, Theodore; Kontos, Athanasios N.; Koratzanis, Georgios; Theodoridou, Maria C.; Mostrou, Glykeria J.; Spoulou, Vana I.; Coughlan, S.; De Gascun, C.; Byrne, C.; Duffy, M.; Bergin, C.; Reidy, D.; Farrell, G.; Lambert, J.; O'Connor, E.; Rochford, A.; Low, J.; Coakely, P.; O'Dea, S.; Hall, W.; Grossman, Z.; Levi, I.; Chemtob, D.; Balotta, Claudia; Franzetti, M.; Lai, A.; Binda, F.; Tramuto, F.; Ciccozzi, M.; Mussini, C.; Angarano, G.; Rezza, G.; Schmit, J. C.; Struck, D.; Hemmer, R.; Arendt, V.; Staub, T.; Schneider, F.; Roman, F.; Wensing, A. M. J.; Boucher, C. A. B.; Van Kessel, A.; van Bentum, P. H. M.; Brinkman, K.; de Coul, E. L.; van der Ende, M. E.; Hoepelman, I. M.; van Kasteren, M.; Juttmann, J.; Kuipers, M.; Langebeek, N.; Richter, C.; Santegoets, R. M. W. J.; Schrijnders-Gudde, L.; Schuurman, R.; van de Ven, B. J. M.; Åsjö, Birgitta; Ormaasen, V.; Aavitsland, P.; Horban, A.; Stanczak, J. J.; Stanczak, G. P.; Firlag-Burkacka, E.; Wiercinska-Drapalo, A.; Jablonowska, E.; Malolepsza, E.; Leszczyszyn-Pynka, M.; Szata, W.; Camacho, Ricardo J.; Palma, C.; Borges, F.; Paixão, T.; Duque, V.; Araújo, F.; Jevtovic, D.; Salemovic, D.; Stanekova, D.; Habekova, M.; Mokráš, Miloš; Truska, P.; Poljak, M.; Lunar, M.; Babic, Dunja Z.; Tomazic, J.; Vidmar, L.; Vovko, T.; Karner, P.; Clotet, B.; Domingo, P.; Galindo, M. J.; Miralles, C.; del Pozo, M. A.; Ribera, E.; Iribarren, J. A.; Ruiz, L.; de la Torre, J.; Vidal, F.; Garcia, F.; Paredes, R.; Albert, Jan; Heidarian, A.; Aperia-Peipke, K.; Axelsson, M.; Mild, M.; Karlsson, A.; Sönnerborg, A.; Thalme, A.; Navér, L.; Bratt, G.; Karlsson, A.; Blaxhult, A.; Gisslén, M.; Svennerholm, B.; Bergbrant, I.; Björkman, Per; Säll, C.; Mellgren, Å.; Lindholm, A.; Kuylenstierna, N.; Montelius, R.; Azimi, F.; Johansson, B.; Carlsson, M.; Johansson, E.; Ljungberg, B.; Ekvall, H.; Strand, A.; Mäkitalo, S.; öberg, S.; Holmblad, P.; Höfer, M.; Holmberg, H.; Josefson, P.; Ryding, U. (2013)
      Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections ...
    • Article  

      Molecular characterization of HIV type 1 strains from newly diagnosed patients in Cyprus (2007-2009) recovers multiple clades including unique recombinant strains and lack of transmitted drug resistance 

      Kousiappa, Ioanna; Achilleos, Charis; Hezka, Johana; Lazarou, Yiota; Othonos, Katerina M.; Demetriades, Ioannis; Kostrikis, Leontios G. (2011)
      HIV-1 evolution generates substantial genetic diversity among isolates, the majority of which are represented in areas where multiple strains cocirculate. A heterogeneous genetic HIV-1 pool has been found in Cyprus, directing ...
    • Article  

      Near full-length genetic analysis of HIV sequences derived from Cyprus: Evidence of a highly polyphyletic and evolving infection 

      Kousiappa, Ioanna; Van De Vijver, D. A. M. C.; Kostrikis, Leontios G. (2009)
      The molecular epidemiology of HIV-1 infection was previously studied in Cyprus but the degree of HIV-1 diversity has remained indefinable. The main objective of the present study is to examine HIV-1 strains isolated from ...
    • Article  

      Patterns of transmitted HIV drug resistance in Europe vary by risk group 

      Frentz, D.; Van De Vijver, D.; Abecasis, A. B.; Albert, Jan; Hamouda, O.; Jørgensen, L.; Kücherer, C.; Struck, D.; Schmit, J. -C; Vercauteren, J.; Åsjö, Birgitta; Balotta, Claudia; Bergin, C.; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Linka, K. L. M.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Vandamme, A. -M; Boucher, C.; Wensing, A. (2014)
      Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
    • Article  

      Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy 

      Sharkey, M. E.; Teo, I.; Greenough, T.; Sharova, N.; Luzuriaga, K.; Sullivan, J. L.; Bucy, R. P.; Kostrikis, Leontios G.; Haase, A.; Veryard, C.; Davaro, R. E.; Cheeseman, S. H.; Daly, J. S.; Bova, C.; Ellison III, R. T.; Mady, B.; Lai, K. K.; Moyle, G.; Nelson, M.; Gazzard, B.; Shaunak, S.; Stevenson, M. (2000)
      Treatment of HIV-1-infected individuals with a combination of anti- retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a reduction in plasma viral RNA to levels below the limit of ...