Browsing by Subject "Models"
Now showing items 41-57 of 57
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Article
Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
(2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Article
Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
(2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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Article
The role of mechanical forces in tumor growth and therapy
(2014)Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
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Article
Role of vascular normalization in benefit from metronomic chemotherapy
(2017)Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
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Article
Second-harmonic generation in a sound beam reflected and transmitted at a curved interface
(2000)This article presents a model for second-harmonic generation in a sound beam that is reflected from or transmitted through a curved interface. Propagation in homogeneous fluids is assumed. Simple analytic solutions are ...
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Article
The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
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Article
Somatization is associated with physical health-related quality of life independent of anxiety and depression in cancer, glaucoma and rheumatological disorders
(2009)Purpose: To test the relative importance of anxiety, depression and somatization as correlates of physical health-related quality of life (HRQOL) in several chronic physical disorders. Methods: In a cross-sectional study ...
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Article
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
(2015)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Conference Object
Surface failure detection for an F/A-18 aircraft using neural networks and fuzzy logic
(IEEE, 1994)In this paper we consider the problem of detecting control surface failures of a high performance aircraft. The detection model is developed using a linear, six degree of freedom dynamic model of an F/A-18 aircraft. The ...
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Article
Synthesis, characterization, and study of octanuclear iron-oxo clusters containing a redox-active Fe4O4-cubane core
(2008)A one-pot synthetic procedure yields the octanuclear FeIII complexes Fe8(μ4-O)4(μ-pz*) 12X4, where X = Cl and pz* = pyrazolate anion (pz = C3H3N2-) (1), 4-Cl-pz (2), and 4-Me-pz (3) or X = Br and pz* = pz (4). The crystal ...
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Article
Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes.
(2012)The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...
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Article
Toward automated generation of parametric BIMs based on hybrid video and laser scanning data
(2010)Only very few constructed facilities today have a complete record of as-built information. Despite the growing use of Building Information Modelling and the improvement in as-built records, several more years will be ...
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Article
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
(2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
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Article
Traffic Modeling and College-Bus Routing Using Entropy Maximization
(2010)A method is presented by which traffic flow estimation between known origins and destinations can be evaluated based on a modified entropy model, and by which bus-routing optimization can be performed. The traffic flow ...
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Article
Unemployment consequences of an aging population: An application of insider-outsider theory
(1989)
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Article
A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth
(2017)Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...
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Article
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: In silico insights
(2016)Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. ...