Browsing by Author "Antoniades, Ioanna"

Now showing items 1-8 of 8

    • Article  

      1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study 

      Charalambous, Anna; Koyioni, Maria; Antoniades, Ioanna; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, L. S.; Rakitin, O. A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
      A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...
    • Article  

      Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells 

      Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)
      We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...
    • Book Chapter  

      Determining Temporal and Spatial Expression of Calpains in Amphibians 

      Charalambous, Anna; Antoniades, Ioanna; Christodoulou, Neophytos; Zanardelli, Sara; Skourides, Paris A. (Springer, 2019)
      Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate important physiological processes by substrate cleavage. Despite the fact that Calpains have been identified in the Xenopus genome, ...
    • Doctoral Thesis  Open Access

      Identification of ciliary adhesion complexes and characterization of the role of FAK in ciliogenesis 

      Antoniades, Ioanna (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2015-11)
      Οι κροσσοί είναι σημαντικές δομές των κυττάρων και αποτελούν οργανίδια τα οποία προεκβάλλουν από την κορυφαία επιφάνεια των κυττάρων συμμετέχοντας σε καθοριστικές λειτουργίες των οργανισμών. Η δυσλειτουργία των κροσσών ...
    • Article  

      In vivo, site-specific, covalent conjugation of quantum dots to proteins via split-intein splicing 

      Charalambous, Anna; Andreou, Maria I.; Antoniades, Ioanna; Christodoulou, Neophytos; Skourides, Paris A. (2012)
      The ability to target proteins with nanostructures and/or nanodevices in vivo is important for understanding and controlling their biological function. Quantum dots (QDs) serve as an ideal model nanostructure due to their ...
    • Article  

      Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton 

      Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)
      Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...
    • Book Chapter  

      Methods of Calpain Inhibition to Determine the Role of Calpains in Embryo Development in Amphibians 

      Antoniades, Ioanna; Charalambous, Anna; Christodoulou, Neophytos; Zanardelli, Sara; Skourides, Paris A. (Springer, 2019)
      Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate important physiological processes by substrate cleavage. Despite the fact that the role of calpains in cell migration and other ...
    • Article  

      Split-Inteins for Simultaneous, site-specific conjugation of Quantum Dots to multiple protein targets In vivo 

      Charalambous, Anna; Antoniades, Ioanna; Christodoulou, Neophytos; Skourides, Paris A. (2011)
      Background: Proteins labelled with Quantum Dots (QDs) can be imaged over long periods of time with ultrahigh spatial and temporal resolution, yielding important information on the spatiotemporal dynamics of proteins within ...