Browsing by Author "Chakrabarti,B."
Now showing items 1-20 of 25
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Atypical neural self-representation in autism
Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Suckling,John; Baron-Cohen,Simon (2010)The 'self' is a complex multidimensional construct deeply embedded and in many ways defined by our relations with the social world. Individuals with autism are impaired in both self-referential and other-referential social ...
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A behavioral comparison of male and female adults with high functioning autism spectrum conditions
Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Wheelwright,Sally J.; Sadek,Susan A.; Chakrabarti,B.; Baron-Cohen,Simon (2011)Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the ...
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Biological sex affects the neurobiology of autism
Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
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Cognition in Males and Females with Autism: Similarities and Differences
Lai,Meng-Chuan; Lombardo,Michael V.; Ruigrok,Amber N. V.; Chakrabarti,B.; Wheelwright,Sally J.; Auyeung, Bonnie; Allison, Carrie; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Williams,Steven C. R.; Baron-Cohen,Simon (2012)The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ...
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The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...
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Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Lai,Meng-Chuan; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)Background: Sex differences are present in many neuropsychiatric conditions that affect emotion and approach-avoidance behavior. One potential mechanism underlying such observations is testosterone in early development. ...
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Fetal testosterone influences sexually dimorphic gray matter in the human brain
Lombardo,Michael V.; Ashwin, Emma; Auyeung, Bonnie; Chakrabarti,B.; Taylor, Kevin; Hackett, Gerald; Bullmore,Edward T.; Baron-Cohen,Simon (2012)In nonhuman species, testosterone is known to have permanent organizing effects early in life that predict later expression of sex differences in brain and behavior. However, in humans, it is still unknown whether such ...
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Frontal networks in adults with autism spectrum disorder
Catani, Marco; Dell’Acqua, Flavio; Budisavljevic, Sanja; Howells, Henrietta; Schotten, Thiebaut De; Froudist-Walsh, Sean; D'Anna, Lucio; Thompson, A.; Sandrone, Stefano; Bullmore,Edward T.; Suckling,John; Baron-Cohen,Simon; Lombardo,Michael V.; Wheelwright,Sally J.; Chakrabarti,B.; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Leemans, Alexander; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2016)It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum ...
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Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Ecker,C.; Sadek,Susan A.; Wheelwright,Sally J.; Murphy,Declan G. M.; Suckling,John; Bullmore,Edward T.; Baron-Cohen,Simon; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Pasco, Greg; Ruigrok,Amber N. V.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2012)Individual differences in cognitive style can be characterized along two dimensions: 'systemizing' (S, the drive to analyze or build 'rule-based' systems) and 'empathizing' (E, the drive to identify another's mental state ...
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Neuroanatomy of individual differences in language in adult males with autism
Lai,Meng-Chuan; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Suckling,John; Bullmore,Edward T.; Happé,Francesca; Murphy,Declan G. M.; Baron-Cohen,Simon (2015)One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural ...
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The neuropsychology of male adults with high-functioning autism or asperger syndrome
Wilson, C. E.; Happé,Francesca; Wheelwright,Sally J.; Ecker,C.; Lombardo,Michael V.; Johnston,Patrick; Daly,Eileen M.; Murphy,Clodagh M.; Spain,D.; Lai,Meng-Chuan; Chakrabarti,B.; Sauter, Disa A.; Baron-Cohen,Simon; Murphy,Declan G. M. (2014)Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, ...
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Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us?
Cadman, T.; Spain,D.; Johnston,Patrick; Russell, A.; Mataix-Cols, D.; Craig, Michael C.; Deeley, Q.; Robertson, D. M.; Murphy,Clodagh M.; Gillan, N.; Wilson, C. E.; Mendez, M.; Ecker,C.; Daly,Eileen M.; Findon, J.; Glaser, K.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R.; Happé,Francesca; Murphy,Clodagh M. (2015)Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD ...
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On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis
Martinez-Murcia, Francisco; Lai,Meng-Chuan; Górriz, Juan Manuel; Ramirez, Javier; Young, Adam M. H.; Deoni,Sean C. L.; Ecker,C.; Lombardo,Michael V.; MRC AIMS Consortium; Baron-Cohen,Simon; Murphy,Declan G. M.; Bullmore,Edward T.; Suckling,John; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Chakrabarti,B.; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2017)Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment ...
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Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay
Balardin, J. B.; Sato, J. R.; Vieira, G.; Feng, Yue; Daly,Eileen M.; Murphy,Clodagh M.; Bailey, Anthony J.; Carrington, S.; Jezzard, Peter; Stewart, R.; Baron-Cohen,Simon; Bullmore,Edward T.; Chakrabarti,B.; Henty, Julian; Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Suckling,John; Wheelwright,Sally J.; Bolton, P. F.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Spain,D.; Williams,Steven C. R.; Wilson, C. E.; Murphy,Clodagh M. (2015)Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the ...
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Response to smith's letter to the editor 'Emotional empathy in Autism spectrum conditions: Weak, Intact, or heightened?'
Minio-Paluello, Ilaria; Lombardo,Michael V.; Chakrabarti,B.; Wheelwright,Sally J.; Baron-Cohen,Simon (2009)
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Self-referential and social cognition in a case of autism and agenesis of the corpus callosum
Lombardo,Michael V.; Chakrabarti,B.; Lai,Meng-Chuan; Baron-Cohen,Simon (2012)Background: While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the ...
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Sex differences in frontal lobe connectivity in adults with autism spectrum conditions
Zeestraten, E. A.; Gudbrandsen, Maria; Daly,Eileen M.; de Schotten, Michel Thiebaut; Catani, Marco; Dell’Acqua, Flavio; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Lombardo,Michael V.; Chakrabarti,B.; Baron-Cohen,Simon; Ecker,C.; Murphy,Declan G. M.; Craig, Michael C. (2017)Autism spectrum conditions (ASC) are more prevalent in males than females. The biological basis of this difference remains unclear. It has been postulated that one of the primary causes of ASC is a partial disconnection ...
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Sex/Gender Differences and Autism: Setting the Scene for Future Research
Lai,Meng-Chuan; Lombardo,Michael V.; Auyeung, Bonnie; Chakrabarti,B.; Baron-Cohen,Simon (2015)Objective The relationship between sex/gender differences and autism has attracted a variety of research ranging from clinical and neurobiological to etiological, stimulated by the male bias in autism prevalence. Findings ...
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A shift to randomness of brain oscillations in people with autism
Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Sadek,Susan A.; Pasco, Greg; Wheelwright,Sally J.; Bullmore,Edward T.; Baron-Cohen,Simon; Suckling,John (2010)Background Resting-state functional magnetic resonance imaging (fMRI) enables investigation of the intrinsic functional organization of the brain. Fractal parameters such as the Hurst exponent, H, describe the complexity ...
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Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
Lombardo,Michael V.; Chakrabarti,B.; Bullmore,Edward T.; Baron-Cohen,Simon (2011)Over the last 25 years, "mindblindness" (deficits in representing mental states) has been one of the primary explanations behind the hallmark social-communication difficulties in autism spectrum conditions (ASC). However, ...