On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis
Date
2017Author
Martinez-Murcia, FranciscoLai,Meng-Chuan
Górriz, Juan Manuel
Ramirez, Javier
Young, Adam M. H.
Deoni,Sean C. L.
Ecker,C.
Lombardo,Michael V.
MRC AIMS Consortium
Baron-Cohen,Simon
Murphy,Declan G. M.
Bullmore,Edward T.
Suckling,John
Bailey, Anthony J.
Baron-Cohen,Simon
Bolton, P. F.
Bullmore,Edward T.
Carrington, S.
Catani, Marco
Chakrabarti,B.
Craig, Michael C.
Daly,Eileen M.
Deoni,Sean C. L.
Ecker,C.
Happé,Francesca
Henty, Julian
Jezzard, Peter
Johnston,Patrick
Jones, D. K.
Lai,Meng-Chuan
Lombardo,Michael V.
Madden, A.
Mullins, D.
Murphy,Clodagh M.
Murphy,Declan G. M.
Pasco, Greg
Ruigrok,Amber N. V.
Sadek,Susan A.
Spain,D.
Stewart, R.
Suckling,John
Wheelwright,Sally J.
Williams,Steven C. R.
Source
Human brain mappingVolume
38Issue
3Pages
1208-1223Google Scholar check
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Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment of larger samples increasing statistical power. However, recent large-scale studies have put some findings into question, considering the results to be strongly dependent on the database used, and demonstrating the substantial heterogeneity within this clinically defined category. One major source of variance may be the acquisition of the data in multiple centres. In this work we analysed the differences found in the multisite, multi-modal neuroimaging database from the UK Medical Research Council Autism Imaging Multicentre Study (MRC AIMS) in terms of both diagnosis and acquisition sites. Since the dissimilarities between sites were higher than between diagnostic groups, we developed a technique called Significance Weighted Principal Component Analysis (SWPCA) to reduce the undesired intensity variance due to acquisition site and to increase the statistical power in detecting group differences. After eliminating site-related variance, statistically significant group differences were found, including Broca's area and the temporo-parietal junction. However, discriminative power was not sufficient to classify diagnostic groups, yielding accuracies results close to random. Our work supports recent claims that ASD is a highly heterogeneous condition that is difficult to globally characterize by neuroimaging, and therefore different (and more homogenous) subgroups should be defined to obtain a deeper understanding of ASD. Hum Brain Mapp 38:1208–1223, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
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Decreased centrality of cortical volume covariance networks in autism spectrum disorders
Balardin, J. B.; Comfort, W. E.; Daly, Eileen M.; Murphy, Clodagh M.; Andrews, Derek Sayre; Murphy, Declan G. M.; Ecker, C.; Sato, J. R.; Bailey, Anthony J.; Baron-Cohen, Simon; Bolton, P. F.; Bullmore, Edward T.; Carrington, S.; Catani, Marco; Chakrabarti, B.; Craig, Michael C.; Daly, Eileen M.; Deoni, Sean C. L.; Happé, Francesca; Henty, Julian; Jezzard, Peter; Johnston, Patrick; Jones, D. K.; Lai, Meng-Chuan; Lombardo, Michael V.; Madden, A.; Mullins, D.; Murphy, Clodagh M.; Murphy, Declan G. M.; Pasco, Greg; Ruigrok, Amber N. V.; Sadek, Susan A.; Spain, D.; Stewart, R.; Suckling, John; Wheelwright, Sally J.; Williams, Steven C. R.; Wilson, C. E.; MRC AIMS Consortium (2015)Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered ...
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Article
Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us?
Cadman, T.; Spain,D.; Johnston,Patrick; Russell, A.; Mataix-Cols, D.; Craig, Michael C.; Deeley, Q.; Robertson, D. M.; Murphy,Clodagh M.; Gillan, N.; Wilson, C. E.; Mendez, M.; Ecker,C.; Daly,Eileen M.; Findon, J.; Glaser, K.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R.; Happé,Francesca; Murphy,Clodagh M. (2015)Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD ...