Browsing by Author "Clardy, J."

Now showing items 1-4 of 4

    • Article  

      FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases 

      Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)
      Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...
    • Article  

      Preparation of a psammaplysene-based library 

      Georgiades, Savvas N.; Clardy, J. (2006)
      (Chemical Equation Presented) A 28-member focused library, based on the pseudosymmetric template of the marine alkaloids psammaplysenes, was prepared from combinations of components that were, in turn, derived from ...
    • Article  

      Synthetic libraries of tyrosine-derived bacterial metabolites 

      Georgiades, Savvas N.; Clardy, J. (2008)
      The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in ...
    • Article  

      Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export 

      Georgiades, Savvas N.; Clardy, J. (2005)
      (Chemical Equation Presented) Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare ...