Browsing by Author "Georgiades, Pantelis"
Now showing items 1-20 of 28
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Article
Balanced translocations for the analysis of imprinted regions of the mouse genome.
Ferguson-Smith, A. C.; Tevendale, M.; Georgiades, Pantelis; Grandjean, V. (2001)Experimental studies that investigate the functional and mechanistic properties of an imprinted locus require material in which the two parental chromosome homologs can be easily distinguished. The use of animals with ...
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Article
Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development
Georgiades, Pantelis; Kieszkiewicz, J.; Rozycka, M.; Brickell, P. M.; Lund, T. (1996)The major histocompatibility complex (MHC) class II-like molecules, H2-M, have an essential role in processing and presentation of antigens by the MHC class II molecules, because functional inactivation of these genes lead ...
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Article
A combined small‐angle X‐ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins
Georgiades, Pantelis; di Cola, Emanuela; Heenan, Richard K.; Pudney, Paul D. A.; Thornton, David J.; Waigh, Thomas A. (2014)
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Article
Comparative developmental anatomy of the murine and human definitive placentae
Georgiades, Pantelis; Fergyson-Smith, A. C.; Burton, G. J. (2002)The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary ...
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Decidual spiral artery remodeling during early post-implantation period in mice: Investigation of associations with decidual uNK cells and invasive trophoblast
Charalambous, F.; Elia, Avraam; Georgiades, Pantelis (2012)Circumferential remodeling of spiral arteries (SAs) during pregnancy is crucial for regulating maternal blood flow into the placenta and clinically important. However its mechanism is still ill defined in humans and mice. ...
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Article
Delta-like and Gtl2 are reciprocally expressed differentially methylated linked imprinted genes on mouse chromosome 12
Takada, S.; Tevendale, M.; Baker, J.; Georgiades, Pantelis; Campbell, E.; Freeman, T.; Johnson, M. H.; Paulsen, M.; Ferguson-Smith, A. C. (2000)The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading ...
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Article
Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis
Georgiades, Pantelis; Brickell, P. M. (1997)Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...
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Article
Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development
Georgiades, Pantelis; Rossant, J. (2006)Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted ...
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Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation
Polydorou, Christiana; Georgiades, Pantelis (2013)Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive ...
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Functional and phenotypic distinction of the first two trophoblast subdivisions and identification of the border between them during early postimplantation: A prerequisite for understanding early patterning during placentogenesis
Nikolaou, Stavros; Hadjikypri, Xenia; Ioannou, Giasemia; Elia, Artemis; Georgiades, Pantelis (2018)The early stages of mouse placentogenesis (placenta formation) involve poorly understood patterning events within polar trophectoderm-derived trophoblast, the progenitor of all placental trophoblast cell types. By early ...
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Article
The mouse Foxi3 transcription factor is necessary for the development of posterior placodes
Birol, O.; Ohyama, T.; Edlund, R. K.; Drakou, Katerina; Georgiades, Pantelis; Groves, A. K. (2016)The inner ear develops from the otic placode, one of the cranial placodes that arise from a region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We have identified a Forkhead family ...
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Book
Mucin structure and mucosal transport of polyphenols
Georgiades, Pantelis; Thornton, David; Waigh, Thomas; University, of Manchester (University of Manchester, 2014)
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Doctoral Thesis
Mucin structure and mucosal transport of polyphenols
Georgiades, Pantelis (University of Manchester, 2014)
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Article
New Insights for Ets2 Function in Trophoblast using Lentivirus-Mediated Gene Knockdown in Trophoblast Stem Cells
Odiatis, C.; Georgiades, Pantelis (2010)Mouse trophoblast stem (TS) cells represent a unique in vitro system that provides an unlimited supply of TS cells for the study of trophoblast differentiation and TS cell self-renewal. Although the mouse transcription ...
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Article
New phenotypic aspects of the decidual spiral artery wall during early post-implantation mouse pregnancy
Elia, Avraam; Charalambous, F.; Georgiades, Pantelis (2011)During pregnancy the walls of decidual spiral arteries (SAs) undergo clinically important structural modifications crucial for embryo survival/growth and maternal health. However, the mechanisms of SA remodeling (SAR) are ...
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Novel spatiotemporal glycome changes in the murine placenta during placentation based on BS-I lectin binding patterns
Charalambous, Christina; Drakou, Katerina; Nicolaou, Stavros; Georgiades, Pantelis (2013)Although spatiotemporal changes of the glycome (full set of glycans, otherwise known as saccharides or carbohydrates) during placenta formation (placentation) are functionally and clinically important, they are poorly ...
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Article
Novel Spatiotemporal Glycome Changes in the Murine Placenta During Placentation Based on BS‐I Lectin Binding Patterns
Charalambous, Christina; Drakou, Katerina; Nicolaou, Stavros; Georgiades, Pantelis (2013)
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Article
Parental origin effects in human trisomy for chromosome 14q: Implications for genomic imprinting
Georgiades, Pantelis; Chierakul, C.; Ferguson-Smith, A. C. (1998)Parental origin specific congenital anomalies have been noted in patients with uniparental disomy of the long arm of human chromosome 14 (UPD14). This suggests the presence of imprinted genes, consistent with observations ...
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Article
Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12
Georgiades, Pantelis; Watkins, M.; Surani, M. A.; Ferguson-Smith, A. C. (2000)Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted
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Article
Particle tracking microrheology of purified gastrointestinal mucins
Georgiades, Pantelis; Pudney, Paul D. A.; Thornton, David J.; Waigh, Thomas A.; Blacklow, Stephen (2014)