Browsing by Author "Georgiades, Savvas N."
Now showing items 1-18 of 18
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Book Chapter
Chapter One - Recent advances in carbazole syntheses
Georgiades, Savvas N.; Nicolaou, Persefoni G. (Academic Press, 2019)The tricyclic carbazole heterocycle is an essential component of many biologically active natural products, drug-like compounds, and valuable π-extended building blocks for advanced materials that exhibit potential for use ...
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Article
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...
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Article
Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes
Georgiades, Savvas N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Firouz Mohd Mustapa, M.; Polychroni, Christoulla; Woscholski, R.; Vilar, R. (2011)The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
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Article
In situ polymerised polyamide 6/sepiolite nanocomposites: Effect of different interphases
Bilotti, E.; Duquesne, E.; Deng, H.; Zhang, R.; Quero, F.; Georgiades, Savvas N.; Fischer, H. R.; Dubois, P.; Peijs, T. (2014)The success of a polymer/clay nanocomposite depends from a number of factors including the intrinsic properties of the clay, nanofiller dispersion and orientation, matrix/filler interactions, etc. This manuscript focuses ...
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Article
Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes
Child, E. S.; Georgiades, Savvas N.; Rose, K. N.; Stafford, V. S.; Patel, C. B. K.; Steinke, J. H. G.; Mann, D. J.; Vilar, R. (2011)Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify ...
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Article
Interaction of metal complexes with G-quadruplex DNA
Georgiades, Savvas N.; Abd Karim, N. H.; Suntharalingam, K.; Vilar, R. (2010)[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several ...
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Article
Interaction of metal complexes with nucleic acids
Georgiades, Savvas N.; Vilar, R. (2010)This chapter reviews the literature reported during 2009 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within ...
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Article
Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity
Rizeq, N.; Georgiades, Savvas N. (2016)Five unprecedented pyridyl-oxazole oligomers exhibiting either linear or branched connectivity of their subunits were developed as a family of potential G-quadruplex-interacting ligands. Our synthesis employed variations ...
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Article
Linear and Branched Pyridyl–Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c‐Myc G‐Quadruplex Helicity
Rizeq, Natalia; Georgiades, Savvas N. (2015)
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
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Article
Preparation of a psammaplysene-based library
Georgiades, Savvas N.; Clardy, J. (2006)(Chemical Equation Presented) A 28-member focused library, based on the pseudosymmetric template of the marine alkaloids psammaplysenes, was prepared from combinations of components that were, in turn, derived from ...
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Article
A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain
Mak, L. H.; Georgiades, Savvas N.; Rosivatz, E.; Whyte, G. F.; Mirabelli, M.; Vilar, R.; Woscholski, R. (2011)Inositol phospholipids have emerged as important key players in a wide variety of cellular functions. Among the seven existing inositol phospholipids, phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) has attracted much ...
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Article
Synthesis and characterization of double-hydrophilic model networks based on cross-linked star polymers of poly(ethylene glycol) methacrylate and methacrylic acid
Georgiades, Savvas N.; Vamvakaki, Maria; Patrickios, Costas S. (2002)A series of model networks based on cross-linked star polymers of poly(ethylene glycol) methacrylate (PEGMA) and tetrahydropyranyl methacrylate (THPMA), a protected form of methacrylic acid (MAA), were synthesized by group ...
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Article
Synthesis of a 'propeller-like' oligoheteroaryl with alternating pyridine and oxazole motifs
Georgiades, Savvas N.; Rizeq, N. (2015)The molecular architecture of oligomeric pyridyl-oxazole compounds is key to determining their mode of interaction with G-quadruplex DNA structures, which is a family of prominent anticancer biomolecular targets. We report ...
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Article
Synthetic libraries of tyrosine-derived bacterial metabolites
Georgiades, Savvas N.; Clardy, J. (2008)The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in ...
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Article
Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export
Georgiades, Savvas N.; Clardy, J. (2005)(Chemical Equation Presented) Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare ...