Browsing by Author "Ho, David D."
Now showing items 1-13 of 13
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A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
Deutsch, L.; Kostrikis, Leontios G.; Huang, Y.; Moore, J. P.; Wolinsky, S. M.; Zhang, L.; Guo, Y.; Phair, J.; Neumann, A. U.; Ho, David D. (1998)Viral and host factors influence the rate of HIV-1 disease progression. For HIV-1 to fuse, a CD4+ cell must express a co-receptor that the virus can use. The chemokine receptors CCR5 and CXCR4 are used by R5 and X4 viruses, ...
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Article
Determining neutralization serotypes of HIV type 1 by neural networks
Kostrikis, Leontios G.; Michalopoulou, Z. -H; Cao, Yun Zhen; Moore, J. P.; Ho, David D. (1996)
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Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Jin, X.; Bauer, D. E.; Tuttleton, S. E.; Lewin, S.; Gettie, A.; Blanchard, J.; Irwin, C. E.; Safrit, J. T.; Mittler, J.; Weinberger, L.; Kostrikis, Leontios G.; Zhang, L.; Perelson, A. S.; Ho, David D. (1999)To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was ...
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Effect of recent thymic emigrants on progression of HIV-1 disease
Hatzakis, Angelos E.; Touloumi, G.; Karanicolas, R.; Karafoulidou, A.; Mandalaki, T.; Anastassopoulou, C. G.; Zhang, L.; Goedert, J. J.; Ho, David D.; Kostrikis, Leontios G. (2000)Background. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of ...
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Effects of in Vivo CD8+ T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine
Metzner, K. J.; Jin, X.; Lee, F. V.; Gettie, A.; Bauer, D. E.; Di Mascio, M.; Perelson, A. S.; Marx, P. A.; Ho, David D.; Kostrikis, Leontios G.; Connor, R. I. (2000)The role of CD8+ T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque ...
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Evidence of two distinct subsubtypes within the HIV-1 subtype A radiation
Gao, F.; Vidal, N.; Li, Y.; Trask, S. A.; Chen, Y.; Kostrikis, Leontios G.; Ho, David D.; Kim, J.; Oh, M. -D; Choe, K.; Salminen, M.; Robertson, D. L.; Shaw, G. M.; Hahn, B. H.; Peeters, M. (2001)Members of HIV-1 group M are responsible for the vast majority of AIDS cases worldwide and have been classified on the basis of their phylogenetic relationships into nine roughly equidistant clades, termed subtypes. Although ...
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Genetic analysis of human immunodeficiency virus type 1 strains from patients in cyprus: Identification of a new subtype designated subtype I
Kostrikis, Leontios G.; Bagdades, Evis K.; Cao, Yun Zhen; Zhang, Lin Qi; Dimitriou, D.; Ho, David D. (1995)DNA sequences encoding the C2 to V3 region of envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) were amplified by PCR from uncultured peripheral blood mononuclear cells obtained from 24 of 25 HIV-1- ...
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Genotyping HIV-1 and HCV strains by a combinatorial DNA melting assay (COMA)
Kostrikis, Leontios G.; Shin, S.; Ho, David D. (1998)Background: Human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) strains can be genetically classified into genetic lineages known as genetic types of subtypes according to phylogenetic analyses of ...
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An isolate of human immunodeficiency virus type 1 originally classified as subtype I represents a complex mosaic comprising three different group M subtypes (A, G, and I)
Gao, F.; Robertson, D. L.; Carruthers, C. D.; Li, Y.; Bailes, E.; Kostrikis, Leontios G.; Salminen, M. O.; Bibollet-Ruche, F.; Peeters, M.; Ho, David D.; Shaw, G. M.; Sharp, P. M.; Hahn, B. H. (1998)Full-length reference clones and sequences are currently available for eight human immunodeficiency virus type 1 (HIV-1) group M subtypes (A through H), but none have been reported for subtypes I and J, which have only ...
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Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
Zhang, L.; Lewin, S. R.; Markowitz, M.; Lin, L. -H; Skulsky, E.; Karanicolas, R.; Yuxian, H.; Xia, J.; Tuttleton, S.; Vesanen, M.; Spiegel, H.; Kost, R.; Van Lunzen, J.; Stellbrink, H. -J; Wolinsky, S.; Borkowsky, W.; Palumbo, P.; Kostrikis, Leontios G.; Ho, David D. (1999)The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) ...
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A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants
Deutsch, L.; Kostrikis, Leontios G.; Neumann, A. U.; Thomson, B.; Korber, B. T.; McHardy, P.; Karanicolas, R.; Huang, Y.; Lew, J. F.; McIntosh, K.; Pollack, H.; Borkowsky, W.; Spiegel, H. M. L.; Palumbo, P.; Oleske, J.; Bardeguez, A.; Luzuriaga, K.; Sullivan, J.; Wolinsky, S. M.; Koup, R. A.; Ho, David D.; Moore, J. P. (1999)There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous ...
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Article
Spectral genotyping of human alleles
Kostrikis, Leontios G.; Tyagi, S.; Mhlanga, M. M.; Ho, David D.; Kramer, F. R. (1998)
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Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy
Lewin, S. R.; Vesanen, M.; Kostrikis, Leontios G.; Hurley, A.; Duran, M.; Zhang, L.; Ho, David D.; Markowitz, M.; Gibson, U. E.; Heid, C. A. (1999)We have designed a novel, precise, and sensitive assay to measure unspliced (US) human immunodeficiency virus type 1 (HIV-1) mRNA in peripheral blood mononuclear cells of HIV-1-infected individuals by using real-time PCR ...