Browsing by Author "Huberman, E."
Now showing items 1-5 of 5
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The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells
Constantinou, Andreas I.; Grdina, D.; Kiguchi, K.; Huberman, E. (1992)Treatment of human K-562-J leukemia cells for 1 h with the topoisomerase II-reactive drugs VP-16, VM-26, or mAMSA resulted in a dose-dependent inhibition of proliferation and in an increase in the percentage of cells ...
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Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action
Constantinou, Andreas I.; Huberman, E. (1995)Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...
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Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells
Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)
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Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein
Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...
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Novobiocin- and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity
Constantinou, Andreas I.; Henning-Chubb, C.; Huberman, E. (1989)Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or ...