Browsing by Author "Kalogirou, Andreas S."
Now showing items 1-20 of 44
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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
Asquith, Christopher R. M.; Godoi, Paulo H.; Couñago, Rafael M.; Laitinen, Tuomo; Scott, John W.; Langendorf, Christopher G.; Oakhill, Jonathan S.; Drewry, David H.; Zuercher, William J.; Koutentis, Panayiotis A.; Willson, Timothy M.; Kalogirou, Andreas S. (2018)We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4 ...
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Article
3,5-Bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-thiadiazin-4-one
Kalogirou, Andreas S.; Koutentis, Panayiotis A. (2019)Stille coupling of 3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-one (10) with 2-(tri-n-butylstannyl)thiazole and Pd(Ph3P)2Cl2 in PhMe, at ca. 110 °
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3-Chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one
Kalogirou, Andreas S.; Koutentis, Panayiotis A. (2019)Stille coupling of 5-chloro-4-oxo-4H-1,2,6-thiadiazin-3-yl trifluoromethanesulfonate (7) with tributyl(3-n-hexylthien-2-yl)stannane and Pd(Ph3P)2Cl2 in PhMe at ca. 20 °C, for 24 h gave 3-chloro-5-(3-n-hexylthien-2-yl)-4H ...
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4-chloro-6-ethoxy-2-(Methylthio)pyrimidine
Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2017)4,6-Dichloro-2-(methylthio) pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 °C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised ...
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4H-1,2,6-Thiadiazin-4-one-containing small molecule donors and additive effects on their performance in solution-processed organic solar cells
Hermerschmidt, F.; Kalogirou, Andreas S.; Min, J.; Zissimou, Georgia A.; Tuladhar, S. M.; Ameri, T.; Faber, H.; Itskos, Grigorios; Choulis, Stelios A.; Anthopoulos, T. D.; Bradley, D. D. C.; Nelson, J.; Brabec, C. J.; Koutentis, Panayiotis Andreas (2015)The optical, electrochemical, morphological and transport properties of a series of thiadiazinone (acceptor) and (thienyl)carbazoles (donor) containing π-extended donor-acceptor-donors (D-A-D) are presented. Systematic ...
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4H-1,2,6-Thiadiazine-containing donor–acceptor conjugated polymers: synthesis, optoelectronic characterization and their use in organic solar cells
Chochos, Christos L.; Kalogirou, Andreas S.; Ye, Tengling; Tatsi, Elisavet; Katsouras, Athanasios; Zissimou, Georgia A.; Gregoriou, Vasilis G.; Avgeropoulos, Apostolos; Koutentis, Panayiotis A. (2018)π-Conjugated donor–acceptor (D–A) polymers containing electron withdrawing non-S-oxidized 4H-1,2,6-thiadiazines and electron donating (het)aryl-substituted indacenodithiophenes (IDTs) were prepared and used in organic solar ...
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5,5′-Bis[5-(9-decyl-9H-carbazol-3-yl)thien-2-yl]-4H,4′H-[3,3′-bi(1,2,6-thiadiazine)]-4,4′-dione
Kalogirou, Andreas S.; Koutentis, Panayiotis A. (2018)Stille coupling of 5,5′-dichloro-4H,4′H-[3,3′-bi(1,2,6-thiadiazine)]-4,4′-dione (8) with 9-decyl-3-[5-(tributylstannyl)thien-2-yl]-9H-carbazole and Pd(Ph3P)2Cl2 in PhMe, at ca. 110 °C, for 2 h, gave 5,5′-bis[5-(9-decyl-9 ...
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5,5′-Thiobis(3-methoxy-4H-1,2,6-thiadiazin-4-one)
Kalogirou, Andreas S.; Koutentis, Panayiotis A. (2019)The reaction of 3-chloro-5-methoxy-4H-1,2,6-thiadiazin-4-one (9) with Na2S·
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The Acid and/or Thermal Mediated Ring Contraction of 4H-1,2,6-Thiadiazines to Afford 1,2,5-Thiadiazoles
Kalogirou, Andreas S.; Kourtellaris, Andreas; Koutentis, Panayiotis Andreas (2016)A near-quantitative acid and/or thermal mediated ring contraction of 3′,5′-diarylspiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazines) affords 3-aryl-4-(2-arylbenzo[d][1,3]dioxol-2-yl)-1,2,5-thiadiazoles. The reaction scope ...
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ChemInform Abstract: Regioselective Geminal Dichloride Reactivity of 3,4,4,5‐Tetrachloro‐4H‐1,2,6‐thiadiazine: Access to 4,4‐Dioxo‐ and Dithio‐Ketals.
Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2016)
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ChemInform Abstract: Ring Transformations of 2‐Hydroxy‐(4‐chloro‐5H‐1,2,3‐dithiazol‐5‐ylideneamino)arenes.
Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2015)
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ChemInform Abstract: Synthesis of 2‐(4H‐1,2,6‐Thiadiazin‐4‐ylidene)malononitriles.
Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2015)
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ChemInform Abstract: Synthesis of N‐Aryl‐3,5‐dichloro‐4H‐1,2,6‐thiadiazin‐4‐imines from 3,4,4,5‐Tetrachloro‐4H‐1,2,6‐thiadiazine.
Kalogirou, Andreas S.; Manoli, Maria; Koutentis, Panayiotis Andreas (2015)
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Article
The Conversion of 5,5′-Bi(1,2,3-dithiazolylidenes) into Isothiazolo[5,4-d]isothiazoles
Konstantinova, Lidia S.; Baranovsky, Ilia V.; Strunyasheva, Vlada V.; Kalogirou, Andreas S.; Popov, Vadim V.; Lyssenko, Konstantin A.; Koutentis, Panayiotis A.; Rakitin, Oleg A. (2018)Thermolysis of 4,4&prime
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The degradation of 4,5-dichloro-1,2,3-dithiazolium chloride in wet solvents
Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2009)4,5-Dichloro-1,2,3-dithiazolium chloride 1 (Appel salt) reacts in wet DCM, THF or MeCN to give elemental sulfur, dithiazole-5-thione 4, dithiazol-5-one 5 and thiazol-5-one 6. Furthermore the reaction of 2-phenylthiazol-5(4H)-one ...
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Evaluation of PVP/Au nanocomposite fibers as heterogeneous catalysts in indole synthesis
Savva, Ioanna; Kalogirou, Andreas S.; Achilleos, Mariliz; Vasile, Eugeniu; Koutentis, Panayiotis Andreas; Krasia‐Christoforou, Theodora (2016)Electrospun nanocomposite fibers consisting of crosslinked polyvinylpyrrolidone (PVP) chains and gold nanoparticles (Au NPs) were fabricated, starting from highly stable PVP/Au NP colloidal solutions with different NP ...
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Pd-catalyzed C-N coupling of primary (het)arylamines with 5-substituted 3-chloro-4H-1,2,6-thiadiazin-4-ones
Kalogirou, Andreas S.; Koutentis, Panayiotis A. (2018)The Buchwald-Hartwig Pd-catalyzed C-N coupling reaction of 5-substituted 3-chloro-4H-1,2,6-thiadiazin-4-ones with primary (het)arylamines is described, affording twenty new 3,5-disubstituted 4H-1,2,6-thiadiazin-4-ones in ...
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The preparation of dicyano-1,3,4-thiadiazole and tricyanothiazole via 1,2,3-dithiazole chemistry
Christoforou, Irene C.; Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2009)Treatment of 1,2-bis(4-chloro-5H-1,2,3-dithiazol-5-ylidene)hydrazine 4 with benzyltriethylammonium iodide (1 equiv) affords dicyano-1,3,4-thiadiazole 3 and 5-cyano-1,3,4-thiadiazole-2-carboxamide 5 in 79 and 21% yields, ...
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PVP-crosslinked electrospun membranes with embedded Pd and Cu2O nanoparticles as effective heterogeneous catalytic supports
Savva, Ioanna; Kalogirou, Andreas S.; Chatzinicolaou, Andrea; Papaphilippou, Petri Ch; Pantelidou, Athena; Vasile, Eugeniu; Tanasǎ, Eugenia; Koutentis, Panayiotis Andreas; Krasia‐Christoforou, Theodora (2014)Palladium(0) (Pd) and copper(i) oxide (Cu2O) nanoparticles (NPs) were successfully embedded in electrospun polyvinylpyrrolidone (PVP) fibrous membranes. The fabrication process involved the synthesis of stable, PVP-capped ...
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A qualitative comparison of the reactivities of 3,4,4,5-Tetrachloro-4H-1,2,6-thiadiazine and 4,5-Dichloro-1,2,3-dithiazolium Chloride
Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2015)The high yielding transformations of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine into 3,5-dichloro-4H-1,2,6-thiadiazin-4-one (up to 85%) and 2-(3,5-dichloro-4H-1,2,6- thiadiazin-4-ylidene)malononitrile (up to 83%) have been ...