Browsing by Author "Kirmizis, Antonis"
Now showing items 1-20 of 21
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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Vermeulen, M.; Mann, M.; Bähler, J.; Green, R. D.; Kouzarides, T. (2007)Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...
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Beyond the histone tail: acetylation at the nucleosome dyad commands transcription.
Molina-Serrano, D.; Kirmizis, Antonis (2013)Post-translational modifications (PTMs) of histones have been implicated in cellular processes such as transcription, replication and DNA repair. These processes normally involve dynamic changes in chromatin structure and ...
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Calorie restriction breaks an epigenetic barrier to longevity
Molina-Serrano, D.; Kirmizis, Antonis (2017)
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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
Kuzmichev, A.; Margueron, R.; Vaquero, A.; Preissner, T. S.; Scher, M.; Kirmizis, Antonis; Ouyang, X.; Brockdorff, N.; Abate-Shen, C.; Farnham, P.; Reinberg, D. (2005)Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to have a profound effect on gene expression through epigenetics. Ezh2 is a histone-lysine ...
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Cross-talk among epigenetic modifications: Lessons from histone arginine methylation
Molina-Serrano, D.; Schiza, V.; Kirmizis, Antonis (2013)Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic ...
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Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway
Pavlou, Demos; Kirmizis, Antonis (2016)Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...
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Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Green, R. D.; Kouzarides, T. (2009)Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its ...
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Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae
Kyriakou, DImitris; Stavrou, Emmanouil; Demosthenous, Panayiota; Angelidou, Georgia; San Luis, B. -J; Boone, Charles M.; Promponas, Vasilis J.; Kirmizis, Antonis (2016)Background: Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role ...
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Genomic approaches that aid in the identification of transcription factor target genes
Kirmizis, Antonis; Farnham, P. J. (2004)It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
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Histone H3 tail clipping regulates gene expression
Santos-Rosa, H.; Kirmizis, Antonis; Nelson, C.; Bartke, T.; Saksouk, N.; Cote, J.; Kouzarides, T. (2009)Induction of gene expression in yeast and human cells involves changes in the histone modifications associated with promoters. Here we identify a histone H3 endopeptidase activity in Saccharomyces cerevisiae that may ...
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Histone Modifications as an Intersection Between Diet and Longevity
Molina-Serrano, Diego; Kyriakou, Dimitris; Kirmizis, Antonis (2019)Histone modifications are key epigenetic regulators that control chromatin structure and gene transcription, thereby impacting on various important cellular phenotypes. Over the past decade, a growing number of studies ...
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Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy
Kirmizis, Antonis; Bartley, S. M.; Farnham, P. J. (2003)We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...
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Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity
Molina-Serrano, D.; Schiza, V.; Demosthenous, Christis; Stavrou, Emmanouil; Oppelt, J.; Kyriakou, DImitris; Liu, W.; Zisser, G.; Bergler, H.; Dang, W.; Kirmizis, Antonis (2016)Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...
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N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing
Schiza, V.; Molina-Serrano, D.; Kyriakou, DImitris; Hadjiantoniou, A.; Kirmizis, Antonis (2013)Post-translational modifications of histones play a key role in DNA-based processes, like transcription, by modulating chromatin structure. N-terminal acetylation is unique among the numerous histone modifications because ...
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NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
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NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
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The Polycomb Group Protein SUZ12 regulates histone H3 lysine 9 methylation and HP1α distribution
De La Cruz, C. C.; Kirmizis, Antonis; Simon, M. D.; Isono, K. -I; Koseki, H.; Panning, B. (2007)Regulation of histone methylation is critical for proper gene expression and chromosome function. Suppressor of Zeste 12 (SUZ12) is a requisite member of the EED/EZH2 histone methyltransferase complexes, and is required ...
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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
Kirmizis, Antonis; Bartley, S. M.; Kuzmichev, A.; Margueron, R.; Reinberg, D.; Green, R.; Farnham, P. J. (2004)Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in ...
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Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory
Bheda, Poonam; Aguilar-Gómez, Diana; Becker, Nils B.; Becker, Johannes; Stavrou, Emmanouil; Kukhtevich, Igor; Höfer, Thomas; Maerkl, Sebastian; Charvin, Gilles; Marr, Carsten; Kirmizis, Antonis; Schneider, Robert (2020)Transcriptional memory of gene expression enables adaptation to repeated stimuli across many organisms. However, the regulation and heritability of transcriptional memory in single cells and through divisions remains poorly ...
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Steps toward understanding the inheritance of repressive methyl-lysine marks in histones
Reinberg, D.; Chuikov, S.; Farnham, P.; Karachentsev, D.; Kirmizis, Antonis; Kuzmichev, A.; Margueron, R.; Nishioka, K.; Preissner, T. S.; Sarma, K.; Abate-Shen, C.; Steward, R.; Vaquero, A. (2004)