Browsing by Author "Koyioni, Maria G."
Now showing items 1-14 of 14
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Article
1,2,3-Dithiazoles – new reversible melanin synthesis inhibitors: a chemical genomics study
Charalambous, Anna; Koyioni, Maria G.; Antoniades, Ioanna A.; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, Lidia S.; Rakitin, Oleg A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
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Article
ChemInform Abstract: Ring Transformations of 2‐Hydroxy‐(4‐chloro‐5H‐1,2,3‐dithiazol‐5‐ylideneamino)arenes.
Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2015)
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Article
ChemInform Abstract: The Reaction of DABCO with 4‐Chloro‐5H‐1,2,3‐dithiazoles: Synthesis and Chemistry of 4‐N‐(2‐Chloroethyl)piperazin‐1‐yl]‐5H‐1,2,3‐dithiazoles.
Koyioni, Maria G.; Manoli, Maria; Koutentis, Panayiotis Andreas (2016)
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Article
The conversion of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines into azine fused thiazole-2-carbonitriles
Koutentis, Panayiotis Andreas; Koyioni, Maria G.; Michaelidou, Sophia S. (2013)The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene) pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2- carbonitriles in low to moderate yields. Introduction, by design, of a ...
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Article
Erratum: Reinvestigating the Reaction of 1H-Pyrazol-5-amines with 4,5-Dichloro-1,2,3-dithiazolium Chloride: A Route to Pyrazolo[3,4-c]isothiazoles and Pyrazolo[3,4-d]thiazoles (Journal of Organic Chemistry (2014) 79 (4025-4037) DOI: 10.1021/jo500509e)
Koyioni, Maria G.; Manoli, Maria; Manos, Manolis J.; Koutentis, Panayiotis Andreas (2015)
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Article
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity
Oppedisano, F.; Catto, M.; Koutentis, Panayiotis Andreas; Nicolotti, O.; Pochini, L.; Koyioni, Maria G.; Introcaso, A.; Michaelidou, Sophia S.; Carotti, A.; Indiveri, C. (2012)The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. A library of 1,2,3-dithiazoles was designed, synthesized and evaluated ...
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Doctoral Thesis Open Access
New ring transformations of 1,2,3-dithiazoles
Koyioni, Maria G. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2017-01)Ο αρχικός στόχος της παρούσας Διατριβής ήταν η διερεύνηση της αντίδρασης μετασχηματισμού Ν-αζινυλ-1,2,3-διθειαζολιμινών προς αζινο-θειαζόλες. Μελέτη της αντίδρασης αυτής οδήγησε στην ανάπτυξη μιας νέας και αποδοτικής ...
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Article
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs
Napolitano, L.; Scalise, M.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas; Catto, M.; Eberini, I.; Parravicini, C.; Palazzolo, L.; Pisani, L.; Galluccio, M.; Console, L.; Carotti, A.; Indiveri, C. (2017)The LAT1 transporter is acknowledged as a pharmacological target of tumours since it is strongly overexpressed in many human cancers. The purpose of this work was to find novel compounds exhibiting potent and prolonged ...
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Article
The Reaction of DABCO with 4-Chloro-5H-1,2,3-dithiazoles: Synthesis and Chemistry of 4-[N-(2-Chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazoles
Koyioni, Maria G.; Manoli, Maria; Koutentis, Panayiotis Andreas (2016)N-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)anilines react with DABCO in hot PhCl to give N-{4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene}anilines in high yields (70-92%). The reaction also works with ...
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Article
Reinvestigating the reaction of 1H-pyrazol-5-amines with 4,5-dichloro-1,2,3-dithiazolium chloride: A route to pyrazolo[3,4-c]isothiazoles and pyrazolo[3,4-d]thiazoles
Koyioni, Maria G.; Manoli, Maria; Manolis, M. J.; Koutentis, Panayiotis Andreas (2014)The reaction of Appel salt 1 with 1H-pyrazol-5-amines 2 gives main products N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines 3, and 6H-pyrazolo[3,4-c]isothiazole-3-carbonitriles 5, together with several minor ...
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Article
Ring transformations of 2-hydroxy-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)arenes
Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2015)Abstract The cyclisation reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene-amino)phenol (5a), 3-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)pyridin-2-ol (5b) and 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)pyridin-3-ol ...
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Article
Synthesis of 5,5′-diarylimino quinoidal 2,2′-bithiazoles
Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2017)A Pd(0)-catalyzed double C-N coupling of 5,5′-dibromo-2,2′-bithiazoles with (het)arylamines and subsequent in situ Ag2O-mediated oxidation provides access to cross-conjugated quinoidal 5,5′-diarylimino-2,2′-bithiazoles in ...
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Article
Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines
Koutentis, Panayiotis Andreas; Koyioni, Maria G.; Michaelidou, Sophia S. (2011)The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3- dithiazolium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5- ylidene)pyridin-Xamines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized ...
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Article
Synthesis of fused 1,2,4-dithiazines and 1,2,3,5-trithiazepines
Koyioni, Maria G.; Manoli, Maria; Koutentis, Panayiotis Andreas (2014)Reacting ( Z)-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines 5 with Et2NH and then with concd H2SO4 gives 5H-pyrazolo[3,4-e ][1,2,4]dithiazine-3-carbonitriles 7 in good yields (74-85%) and 6H-pyrazolo-[3,4 ...