Browsing by Author "Michaelidou, Sophia S."
Now showing items 1-16 of 16
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1,2,3-Dithiazole chemistry in heterocyclic synthesis
Christoforou, Irene C.; Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2006)The chemistry of various 5H-1,2,3-dithiazoles is investigated with emphasis on assisted ring opening and ring closure reactions leading to new heterocycles. Thus on treatment with catalytic tetraalkylammonium iodide ...
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1,2,3-Dithiazoles – new reversible melanin synthesis inhibitors: a chemical genomics study
Charalambous, Anna; Koyioni, Maria G.; Antoniades, Ioanna A.; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, Lidia S.; Rakitin, Oleg A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
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1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study
Charalambous, Anna; Koyioni, Maria; Antoniades, Ioanna; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, L. S.; Rakitin, O. A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...
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3-amino-6-ethoxy-4-phenyl-1H-pyrrolo[2,3-b]pyridine-2,5-dicarbonitrile
Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2010)(Z)-2-(4-Chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine- 3,5-dicarbonitrile 1, when treated with either triphenylphosphine (4 equiv.) or polymer bound triphenylphosphine (5 equiv.) in dichloromethane ...
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ChemInform Abstract: Ring Transformations of 2‐Hydroxy‐(4‐chloro‐5H‐1,2,3‐dithiazol‐5‐ylideneamino)arenes.
Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2015)
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The conversion of 2-(4-chloro-5H-1,2,3-dithiazolylideneamino)benzonitriles into 3-aminoindole-2-carbonitriles using triphenylphosphine
Michaelidou, Sophia S.; Koutentis, Panayiotis Andreas (2009)2-(4-Chloro-5H-1,2,3-dithiazolylideneamino)benzonitrile 1a reacts with triphenylphosphine (4 equiv) in the presence of water (2 equiv) to afford anthranilonitrile 2a, 3-aminoindole-2-carbonitrile 3a and (2-cyanoindol-3-y ...
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The conversion of 2-cyano cyanothioformanilides into 3-aminoindole-2- carbonitriles using triphenylphosphine
Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2010)2-Cyano cyanothioformanilide 3a reacts with triphenylphosphine in the presence of water to give 2-(cyanomethyleneamino)benzonitrile 4a, 2-(cyanomethylamino)benzonitrile 5, 3-aminoindole-2-carbonitrile 2a and (2-cyanoindo ...
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The conversion of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines into azine fused thiazole-2-carbonitriles
Koutentis, Panayiotis Andreas; Koyioni, Maria G.; Michaelidou, Sophia S. (2013)The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene) pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2- carbonitriles in low to moderate yields. Introduction, by design, of a ...
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Detosylation of 3-amino-1-tosylindole-2-carbonitriles using DBU and thiophenol
Michaelidou, Sophia S.; Koutentis, Panayiotis Andreas (2010)Attempted detosylation of the 3-amino-1-(p-tosylamino)indole-2-carbonitriles 4a-c using either K2CO3 in EtOH or DBU in PhH at reflux gives unexpectedly the 3-(N-p-tosylamino)indole-2-carbonitriles 5a-c, respectively in ...
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Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity
Oppedisano, F.; Catto, M.; Koutentis, Panayiotis Andreas; Nicolotti, O.; Pochini, L.; Koyioni, Maria G.; Introcaso, A.; Michaelidou, Sophia S.; Carotti, A.; Indiveri, C. (2012)The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. A library of 1,2,3-dithiazoles was designed, synthesized and evaluated ...
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Microwave assisted synthesis of 3-aminoindole-2-carbonitriles from anthranilonitriles via N-unprotected 2-(cyanomethylamino)benzonitriles
Michaelidou, Sophia S.; Koutentis, Panayiotis Andreas (2010)Anthranilonitrile 3a, 4,5-dimethoxyanthranilonitrile 3b and 5-nitroanthranilonitrile 3c, react with paraformaldehyde, KCN and ZnCl2 in acetic acid under acid catalysis (H2SO4) in a sealed tube at ca. 55 °C to give the ...
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Ring transformations of 2-hydroxy-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)arenes
Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria G.; Koutentis, Panayiotis Andreas (2015)Abstract The cyclisation reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene-amino)phenol (5a), 3-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)pyridin-2-ol (5b) and 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)pyridin-3-ol ...
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The synthesis of 2-cyano-cyanothioformanilides from 2-(4-Chloro-5H-1,2,3- dithiazol-5-ylideneamino)benzonitriles using DBU
Michaelidou, Sophia S.; Koutentis, Panayiotis Andreas (2009)A series of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino) benzonitriles were prepared from the reaction of 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) and the corresponding anthranilonitriles. Reaction of the ...
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Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines
Koutentis, Panayiotis Andreas; Koyioni, Maria G.; Michaelidou, Sophia S. (2011)The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3- dithiazolium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5- ylidene)pyridin-Xamines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized ...
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Transformation of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile into 4-aminopyrido[2,3-d]pyrimidines and 2-(pyrid-2-yl)guanidines
Kalogirou, Andreas S.; Michaelidou, Sophia S.; White, A. J. P.; Koutentis, Panayiotis Andreas (2015)The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave ...
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(Z)-2-(4-chloro-5h-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile
Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2010)2-Amino-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile 1 reacts with 4,5-dichloro-1,2,3-dithiazolium chloride 2 in the presence of pyridine (2 equiv.) to afford (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4 ...