Browsing by Author "Ruigrok,Amber N. V."
Now showing items 1-12 of 12
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A behavioral comparison of male and female adults with high functioning autism spectrum conditions
Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Wheelwright,Sally J.; Sadek,Susan A.; Chakrabarti,B.; Baron-Cohen,Simon (2011)Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the ...
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Biological sex affects the neurobiology of autism
Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
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Cognition in Males and Females with Autism: Similarities and Differences
Lai,Meng-Chuan; Lombardo,Michael V.; Ruigrok,Amber N. V.; Chakrabarti,B.; Wheelwright,Sally J.; Auyeung, Bonnie; Allison, Carrie; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Williams,Steven C. R.; Baron-Cohen,Simon (2012)The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ...
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The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...
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Frontal networks in adults with autism spectrum disorder
Catani, Marco; Dell’Acqua, Flavio; Budisavljevic, Sanja; Howells, Henrietta; Schotten, Thiebaut De; Froudist-Walsh, Sean; D'Anna, Lucio; Thompson, A.; Sandrone, Stefano; Bullmore,Edward T.; Suckling,John; Baron-Cohen,Simon; Lombardo,Michael V.; Wheelwright,Sally J.; Chakrabarti,B.; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Leemans, Alexander; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2016)It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum ...
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Imaging sex/gender and autism in the brain: Etiological implications
Lai,Meng-Chuan; Lerch, Jason P.; Floris, Dorothea L.; Ruigrok,Amber N. V.; Pohl, A.; Lombardo,Michael V.; Baron-Cohen,Simon (2017)The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform ...
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Improving effect size estimation and statistical power with multi-echo fMRI and its impact on understanding the neural systems supporting mentalizing
Lombardo,Michael V.; Auyeung, Bonnie; Holt, R. J.; Waldman, Jack; Ruigrok,Amber N. V.; Mooney, Natasha; Bullmore,Edward T.; Baron-Cohen,Simon; Kundu, Prantik (2016)Functional magnetic resonance imaging (fMRI) research is routinely criticized for being statistically underpowered due to characteristically small sample sizes and much larger sample sizes are being increasingly recommended. ...
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Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Ecker,C.; Sadek,Susan A.; Wheelwright,Sally J.; Murphy,Declan G. M.; Suckling,John; Bullmore,Edward T.; Baron-Cohen,Simon; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Pasco, Greg; Ruigrok,Amber N. V.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2012)Individual differences in cognitive style can be characterized along two dimensions: 'systemizing' (S, the drive to analyze or build 'rule-based' systems) and 'empathizing' (E, the drive to identify another's mental state ...
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On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis
Martinez-Murcia, Francisco; Lai,Meng-Chuan; Górriz, Juan Manuel; Ramirez, Javier; Young, Adam M. H.; Deoni,Sean C. L.; Ecker,C.; Lombardo,Michael V.; MRC AIMS Consortium; Baron-Cohen,Simon; Murphy,Declan G. M.; Bullmore,Edward T.; Suckling,John; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Chakrabarti,B.; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2017)Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment ...
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Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay
Balardin, J. B.; Sato, J. R.; Vieira, G.; Feng, Yue; Daly,Eileen M.; Murphy,Clodagh M.; Bailey, Anthony J.; Carrington, S.; Jezzard, Peter; Stewart, R.; Baron-Cohen,Simon; Bullmore,Edward T.; Chakrabarti,B.; Henty, Julian; Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Suckling,John; Wheelwright,Sally J.; Bolton, P. F.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Spain,D.; Williams,Steven C. R.; Wilson, C. E.; Murphy,Clodagh M. (2015)Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the ...
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Sex differences in frontal lobe connectivity in adults with autism spectrum conditions
Zeestraten, E. A.; Gudbrandsen, Maria; Daly,Eileen M.; de Schotten, Michel Thiebaut; Catani, Marco; Dell’Acqua, Flavio; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Lombardo,Michael V.; Chakrabarti,B.; Baron-Cohen,Simon; Ecker,C.; Murphy,Declan G. M.; Craig, Michael C. (2017)Autism spectrum conditions (ASC) are more prevalent in males than females. The biological basis of this difference remains unclear. It has been postulated that one of the primary causes of ASC is a partial disconnection ...
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Unsupervised data-driven stratification of mentalizing heterogeneity in autism
Lombardo,Michael V.; Lai,Meng-Chuan; Auyeung, Bonnie; Holt, R. J.; Allison, Carrie; Smith, P.; Chakrabarti,B.; Ruigrok,Amber N. V.; Suckling,John; Bullmore,Edward T.; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Happé,Francesca; Baron-Cohen,Simon (2016)Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a ...