Browsing by Author "Savva, Christiana G."
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Article
LiSIs: An online scientific workflow system for virtual screening
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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Article
LiSIs: An online scientific workflow system for virtual screeningAAA
Kannas, Christos C.; Kalvari, Ioanna; Lambrinidis, George; Neophytou, Christiana M.; Savva, Christiana G.; Kirmitzoglou, Ioannis K.; Antoniou, Zinonas C.; Achilleos, Kleo G.; Scherf, D.; Pitta, Chara A.; Nicolaou, Christos A.; Mikros, Emmanuel; Promponas, Vasilis J.; Gerhauser, C.; Mehta, R. G.; Constantinou, Andreas I.; Pattichis, Constantinos S. (2015)Modern methods of drug discovery and development in recent years make a wide use of computational algorithms. These methods utilise Virtual Screening (VS), which is the computational counterpart of experimental screening. ...
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Doctoral Thesis Open Access
Selective activation of TNFR1 and NF-kB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells
Savva, Christiana G. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2016-05)Το KC-53 είναι ένα νεοσυντιθέμενο biyouyanagin ανάλογο μόριο με γνωστή ισχυρή αντιφλεγμονώδη και αντιική δράση. Στην παρούσα εργασία, διερευνήσαμε την αντιπολλαπλασιαστική του δράση σε 13 αντιπροσωπευτικές ανθρώπινες ...
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Article
Selective activation of TNFR1 and NF-ΚB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells
Savva, Christiana G.; Totokotsopoulos, S.; Nicolaou, K. C.; Neophytou, Christiana M.; Constantinou, Andreas I. (2016)Background: Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance. ...