Browsing by Author "Stylianou, Panayiota"
Now showing items 1-10 of 10
-
Article
Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos
Petridou, Nicoletta I.; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel S.; Guan, Junlin; Skourides, Paris A. (2012)Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...
-
Article
Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells
Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...
-
Doctoral Thesis Open Access
Addressing the molecular basis of morphogenetic movements during Xenopus gastrulation with the use of quantum dot nanocrystals : the role of Focal Adhesion Kinase (FAK) during Xenopus development
Stylianou, Panayiota (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2011-06)Σε αυτή τη μελέτη αποδεικνύουμε ότι η ενεργοποίηση της FAK με βάση τις ιντεγκρίνες είναι απαραίτητη για τη μεσοδερμική μετανάστευση όχι όμως για τη συγκλίνουσα επέκταση. Η αναστολή της FAK με έκφραση του γνωστού αρνητικού ...
-
Article
A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis
Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...
-
Article
Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals
Stylianou, Panayiota; Skourides, Paris A. (2009)Mesoderm migration is a well studied morphogenetic movement that takes place during Xenopus gastrulation. The study of mesoderm migration and other morphogenetic movements has been primarily based on in vitro assays due ...
-
Article
Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton
Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...
-
Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
-
Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
-
Article
A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria
Ilmi, Rashid; Tseriotou, Eleni; Stylianou, Panayiota; Christou, Yiota A.; Ttofi, Iakovia; Dietis, Nikolas; Pitris, Costas; Odysseos, Andreani D.; Georgiades, Savvas N. (2019)The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function in malignancies has been linked to severe irregularities in critical cellular processes, including cell cycle ...
-
Article
Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development
Demetriou, Manolis C.; Stylianou, Panayiota; Andreou, Maria I.; Yiannikouri, Olga; Tsaprailis, George; Cress, Anne E.; Skourides, Paris A. (2008)The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates ...