Browsing by Subject "Chemoprevention"
Now showing items 1-11 of 11
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Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
(2010)A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ...
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Developing the evidence base for cancer chemoprevention: Use of meta-analysis
(2011)Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...
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Article
Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis
(1997)In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...
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Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
(2004)Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...
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Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
(1998)Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...
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Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function
(1997)The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...
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Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones
(1996)Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...
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Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats
(2003)The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. ...
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Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity
(2000)The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...
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The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours
(2005)The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, ...
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Soy protein isolate prevents chemically-induced rat mammary tumors
(2002)purified daidzein at 200 mg/kg diet