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Browsing by Subject "Chemoprevention"

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    • Article  

      Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Filioussi, K.; Peponi, Evangelia; Bagos, Pantelis G.; Sitaras, N. M. (2010)
      A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ...

    • Article  

      Developing the evidence base for cancer chemoprevention: Use of meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)
      Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

    • Article  

      Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis 

      Moon, R. C.; Constantinou, Andreas I. (1997)
      In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...

    • Article  

      Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice 

      Murillo, G.; Choi, J. K.; Pan, O.; Constantinou, Andreas I.; Mehta, R. G. (2004)
      Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...

    • Article  

      Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice 

      Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)
      Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

    • Article  

      Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function 

      Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)
      The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...

    • Article  

      Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones 

      Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)
      Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...

    • Article  

      Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats 

      Constantinou, Andreas I.; Mehta, R.; Husband, A. (2003)
      The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. ...

    • Article  

      Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity 

      Cho, K. H.; Pezzuto, J. M.; Bolton, J. L.; Steele, V. E.; Kelloff, G. J.; Lee, S. K.; Constantinou, Andreas I. (2000)
      The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...

    • Article  

      The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours 

      Constantinou, Andreas I.; White, B. E. P.; Tonetti, D.; Yang, Y.; Liang, W.; Li, W.; Van Breemen, R. B. (2005)
      The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, ...

    • Article  

      Soy protein isolate prevents chemically-induced rat mammary tumors 

      Constantinou, Andreas I.; Morgan Lucas, L.; Lantvit, D.; Hawthorne, M.; Xu, X.; Chu, W. N.; Jeffery, E. H.; Christov, K.; Van Breemen, R. B.; Pezzuto, J. M. (2002)
      purified daidzein at 200 mg/kg diet

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