Developing the evidence base for cancer chemoprevention: Use of meta-analysis
Date
2011Source
Current Drug TargetsVolume
12Issue
13Pages
1989-1997Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an explicit methodology section, employs strategies to minimize bias, yields objective findings and enables evidence-based decisions. In this review, we examine meta-analysis taking examples from the field of cancer chemoprevention, an innovative area of cancer research that focuses on the prevention of cancer through pharmacological, biologic, and nutritional interventions. In particular, we consider the practical steps involved in the conduct of a meta-analysis, illustrate the statistical techniques for the calculation of summary estimates, present the available methodology for detecting and minimizing bias and, finally, we discuss unresolved issues and future applications. © 2011 Bentham Science Publishers.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Cancer of unknown primary site
Pavlidis, Nicholas; Pentheroudakis, George (2012)Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...
-
Article
«Juvenile» oncology - A missing subspecialty. The experience of a reference cancer centre
Pentheroudakis, George; Mauri, D.; Kostadima, Lida; Golfinopoulos, Vassilis; Alexiou, G.; Karakatsanis, A.; Pavlidis, Nicholas (2006)Introduction: Despite unique tumor epidemiology and a higher cancer incidence compared to pediatric patients, adolescents and young adults have not been receiving specialized, multidisciplinary, centralized care. In an ...
-
Article
Probing the unknown in cancer of unknown primary: Which way is the right way?
Pentheroudakis, George; Pavlidis, Nicholas (2010)