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Browsing by Subject "Meta-analysis"

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    • Article  

      The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)
      Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...

    • Article  

      Bisphosphonate use and risk of colorectal cancer: A systematic review and meta-analysis 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2013)
      Aim: A growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. Methods: ...

    • Article  

      Cancer treatment reviews welcomes submission of the Cochrane Reviews 

      Pavlidis, Nicholas; Stahel, R. A.; Clarke, M.; Djulbegovic, B. (2006)

    • Article  

      Chlamydia pneumoniae infection and the risk of multiple sclerosis: A meta-analysis 

      Bagos, Pantelis G.; Nikolopoulos, Georgios K.; Ioannidis, A. (2006)
      We conducted a meta-analysis of studies comparing the presence of Chlamydia pneumoniae (Cpn) between multiple sclerosis (MS) patients and other neurological diseases patients or healthy controls. We identified 26 studies ...

    • Article  

      Condom effectiveness in reducing heterosexual HIV transmission: a systematic review and meta-analysis of studies on HIV serodiscordant couples 

      Giannou, Foteini K.; Tsiara, Chrissa G.; Nikolopoulos, Georgios K.; Talias, M.; Benetou, Vasiliki; Kantzanou, Maria; Bonovas, Stefanos; Hatzakis, A. (2016)
      Objective: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. Methods: Medline, Scopus, and the ISI Web of Science databases were searched ...

    • Article  

      Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls 

      Nikolopoulos, Georgios K.; Masgala, Aikaterini; Tsiara, Chrissa G.; Limitsiou, O. K.; Karnaouri, Anthi C.; Dimou, Niki L.; Bagos, Pantelis G. (2011)
      Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...

    • Article  

      Cytokine gene polymorphisms in periodontal disease: A meta-analysis of 53 studies including 4178 cases and 4590 controls 

      Nikolopoulos, Georgios K.; Dimou, Niki L.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2008)
      Aim: We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. Material and Methods: A ...

    • Article  

      Developing the evidence base for cancer chemoprevention: Use of meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)
      Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

    • Article  

      Effects of different chemotherapy regimens on survival for advanced cervical cancer: Systematic review and meta-analysis 

      Tzioras, S.; Pavlidis, Nicholas; Paraskevaidis, E.; Ioannidis, J. P. A. (2007)
      Background: A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits. Methods: We searched (last ...

    • Article  

      Fc gamma receptor polymorphisms and their association with periodontal disease: a meta-analysis 

      Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)
      Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fc gamma receptor (Fc gamma R) polymorphisms with susceptibility to aggressive and chronic periodontal disease. ...

    • Article  

      Fcγ receptor polymorphisms and their association with periodontal disease: A meta-analysis 

      Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)
      Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials ...

    • Article  

      Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology 

      Bagos, Pantelis G.; Nikolopoulos, Georgios K. (2009)
      Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ...

    • Article  

      The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of 34 studies including 14 094 cases and 17 760 controls 

      Bagos, Pantelis G.; Elefsinioti, Antigoni L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J. (2007)
      OBJECTIVES: The C825T single nucleotide polymorphism of the G-protein β3 (GNB3) has been implicated in susceptibility to essential hypertension, through the expression of an alternatively spliced truncated variant. In an ...

    • Article  

      Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis 

      Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Bagos, Pantelis G.; Travlou, Anthi S.; Vaiopoulos, G. (2007)
      Introduction: Platelet adhesion to fibrillar collagen via the membrane glycoprotein (GP) Ia/IIa (α2β1), is a crucial event in the pathogenesis of arterial occlusive disorders. The C807T single nucleotide polymorphism of ...

    • Article  

      Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Vaiopoulos, G.; Travlou, Anthi S. (2007)
      Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism ...

    • Article  

      Levels of absolute survival benefit for systemic therapies of advanced cancer: A call for standards 

      Ioannidis, J. P. A.; Pavlidis, Nicholas (2003)
      Research on systemic interventions in patients with advanced stage malignancies should be systematised with an emphasis on the absolute gain in survival for the median patient. Such information is most meaningful with ...

    • Article  

      Marketing strategy determinants of export performance: A meta-analysis 

      Leonidou, Leonidas C.; Katsikeas, Constantine S.; Samiee, Saeed (2002)
      Identifying the marketing strategy elements that influence export performance has been the subject of sizeable empirical research. However, the findings reported in the literature are characterized by fragmentation and ...

    • Article  

      Meta-analysis of family-based and case-control genetic association studies that use the same cases 

      Bagos, Pantelis G.; Dimou, Niki L.; Liakopoulos, Theodore D.; Nikolopoulos, Georgios K. (2011)
      In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ...

    • Article  

      A meta-analysis of sex differences in human brain structure 

      Ruigrok, Amber N. V.; Salimi-Khorshidi, G.; Lai, Meng-Chuan; Baron-Cohen, Simon; Lombardo, Michael V.; Tait, Roger J.; Suckling, John (2014)
      The prevalence, age of onset, and symptomatology of many neuropsychiatric conditions differ between males and females. To understand the causes and consequences of sex differences it is important to establish where they ...

    • Article  

      A method for meta-analysis of case-control genetic association studies using logistic regression 

      Bagos, Pantelis G.; Nikolopoulos, Georgios K. (2007)
      We propose here a simple and robust approach for meta-analysis of molecular association studies. Making use of the binary structure of the data, and by treating the genotypes as independent variables in a logistic regression, ...

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