Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls
Date
2011Author
![ORCID logo](https://orcid.org/sites/default/files/images/orcid_16x16.png)
Masgala, Aikaterini
Tsiara, Chrissa G.
Limitsiou, O. K.
![ORCID logo](https://orcid.org/sites/default/files/images/orcid_16x16.png)
Dimou, Niki L.
![ORCID logo](https://orcid.org/sites/default/files/images/orcid_16x16.png)
Source
European Journal of NeurologyVolume
18Issue
7Pages
944-951Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the potential association between various cytokine gene polymorphisms and the occurrence of multiple sclerosis. A comprehensive literature search yielded 45 eligible studies, which involved 7379 cases and 8131 controls. Totally, the effect of eight polymorphisms, i.e. IL-1A C[-889]T, IL-1B C[-511]T, IL-1B C[3953]T, IL-4 C[33]T, IL-10 C[-819]T, IL-10G[-1082]A, tumour necrosis factor-a (TNFA) G[-308]A and TNFA G[-238]A, was evaluated in a random-effects meta-analysis. There was no evidence of statistically significant association between the aforementioned polymorphisms and multiple sclerosis. Publication bias and heterogeneity were absent in most analyses. Within its limitations, the current literature-based meta-analysis does not indicate that specific polymorphic variations of genes encoding pro-inflammatory and anti-inflammatory cytokines affect susceptibility to multiple sclerosis. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Cytokine gene polymorphisms in periodontal disease: A meta-analysis of 53 studies including 4178 cases and 4590 controls
Nikolopoulos, Georgios K.; Dimou, Niki L.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2008)Aim: We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. Material and Methods: A ...
-
Article
Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis
Wozniak, Greta; Toska, Aikaterini; Saridi, Maria; Mouzas, Odysseas (2011)Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was ...
-
Article
Depression in cancer: The many biobehavioral pathways driving tumor progression
Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...