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dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorMasgala, Aikaterinien
dc.contributor.authorTsiara, Chrissa G.en
dc.contributor.authorLimitsiou, O. K.en
dc.contributor.authorKarnaouri, Anthi C.en
dc.contributor.authorDimou, Niki L.en
dc.contributor.authorBagos, Pantelis G.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorMasgala, Aikaterinien
dc.creatorTsiara, Chrissa G.en
dc.creatorLimitsiou, O. K.en
dc.creatorKarnaouri, Anthi C.en
dc.creatorDimou, Niki L.en
dc.creatorBagos, Pantelis G.en
dc.date.accessioned2018-06-22T09:54:09Z
dc.date.available2018-06-22T09:54:09Z
dc.date.issued2011
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42215
dc.description.abstractMany environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the potential association between various cytokine gene polymorphisms and the occurrence of multiple sclerosis. A comprehensive literature search yielded 45 eligible studies, which involved 7379 cases and 8131 controls. Totally, the effect of eight polymorphisms, i.e. IL-1A C[-889]T, IL-1B C[-511]T, IL-1B C[3953]T, IL-4 C[33]T, IL-10 C[-819]T, IL-10G[-1082]A, tumour necrosis factor-a (TNFA) G[-308]A and TNFA G[-238]A, was evaluated in a random-effects meta-analysis. There was no evidence of statistically significant association between the aforementioned polymorphisms and multiple sclerosis. Publication bias and heterogeneity were absent in most analyses. Within its limitations, the current literature-based meta-analysis does not indicate that specific polymorphic variations of genes encoding pro-inflammatory and anti-inflammatory cytokines affect susceptibility to multiple sclerosis. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS.en
dc.language.isoengen
dc.sourceEuropean Journal of Neurologyen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectPublicationen
dc.subjectReviewen
dc.subjectInformation retrievalen
dc.subjectGenetic associationen
dc.subjectSingle nucleotide polymorphismen
dc.subjectMeta analysisen
dc.subjectPolymorphismen
dc.subjectSingle nucleotideen
dc.subjectGenetic predisposition to diseaseen
dc.subjectMultiple sclerosisen
dc.subjectMedlineen
dc.subjectInterleukin 10en
dc.subjectInterleukin 1betaen
dc.subjectImmunoregulationen
dc.subjectImmune responseen
dc.subjectInterleukin 4en
dc.subjectTumor necrosis factor alphaen
dc.subjectInterleukin 1alphaen
dc.subjectCytokinesen
dc.subjectGenetic variabilityen
dc.subjectInterleukinen
dc.subjectSingle-nucleotide polymorphismen
dc.subjectTumour necrosis factoren
dc.titleCytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controlsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/j.1468-1331.2011.03355.x
dc.description.volume18
dc.description.issue7
dc.description.startingpage944
dc.description.endingpage951
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.contributor.orcidKarnaouri, Anthi C. [0000-0001-9164-7667]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325
dc.gnosis.orcid0000-0001-9164-7667


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