dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Masgala, Aikaterini | en |
dc.contributor.author | Tsiara, Chrissa G. | en |
dc.contributor.author | Limitsiou, O. K. | en |
dc.contributor.author | Karnaouri, Anthi C. | en |
dc.contributor.author | Dimou, Niki L. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Masgala, Aikaterini | en |
dc.creator | Tsiara, Chrissa G. | en |
dc.creator | Limitsiou, O. K. | en |
dc.creator | Karnaouri, Anthi C. | en |
dc.creator | Dimou, Niki L. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.date.accessioned | 2018-06-22T09:54:09Z | |
dc.date.available | 2018-06-22T09:54:09Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42215 | |
dc.description.abstract | Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the potential association between various cytokine gene polymorphisms and the occurrence of multiple sclerosis. A comprehensive literature search yielded 45 eligible studies, which involved 7379 cases and 8131 controls. Totally, the effect of eight polymorphisms, i.e. IL-1A C[-889]T, IL-1B C[-511]T, IL-1B C[3953]T, IL-4 C[33]T, IL-10 C[-819]T, IL-10G[-1082]A, tumour necrosis factor-a (TNFA) G[-308]A and TNFA G[-238]A, was evaluated in a random-effects meta-analysis. There was no evidence of statistically significant association between the aforementioned polymorphisms and multiple sclerosis. Publication bias and heterogeneity were absent in most analyses. Within its limitations, the current literature-based meta-analysis does not indicate that specific polymorphic variations of genes encoding pro-inflammatory and anti-inflammatory cytokines affect susceptibility to multiple sclerosis. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS. | en |
dc.language.iso | eng | en |
dc.source | European Journal of Neurology | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Priority journal | en |
dc.subject | Publication | en |
dc.subject | Review | en |
dc.subject | Information retrieval | en |
dc.subject | Genetic association | en |
dc.subject | Single nucleotide polymorphism | en |
dc.subject | Meta analysis | en |
dc.subject | Polymorphism | en |
dc.subject | Single nucleotide | en |
dc.subject | Genetic predisposition to disease | en |
dc.subject | Multiple sclerosis | en |
dc.subject | Medline | en |
dc.subject | Interleukin 10 | en |
dc.subject | Interleukin 1beta | en |
dc.subject | Immunoregulation | en |
dc.subject | Immune response | en |
dc.subject | Interleukin 4 | en |
dc.subject | Tumor necrosis factor alpha | en |
dc.subject | Interleukin 1alpha | en |
dc.subject | Cytokines | en |
dc.subject | Genetic variability | en |
dc.subject | Interleukin | en |
dc.subject | Single-nucleotide polymorphism | en |
dc.subject | Tumour necrosis factor | en |
dc.title | Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/j.1468-1331.2011.03355.x | |
dc.description.volume | 18 | |
dc.description.issue | 7 | |
dc.description.startingpage | 944 | |
dc.description.endingpage | 951 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.contributor.orcid | Karnaouri, Anthi C. [0000-0001-9164-7667] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |
dc.gnosis.orcid | 0000-0001-9164-7667 | |