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Browsing by Subject "Exon"

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    • Article  

      Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target? 

      Dova, L.; Pentheroudakis, George; Georgiou, I.; Malamou-Mitsi, Vassiliki D.; Vartholomatos, G.; Fountzilas, George; Kolaitis, N.; Kitsou, E.; Pavlidis, Nicholas (2007)
      Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...

    • Article  

      KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study 

      Negru, S.; Papadopoulou, E.; Apessos, A.; Stanculeanu, D. L.; Ciuleanu, E.; Volovat, C.; Croitoru, A.; Kakolyris, S.; Aravantinos, Gerasimos; Ziras, N.; Athanasiadis, E.; Touroutoglou, N.; Pavlidis, Nicholas; Kalofonos, H. P.; Nasioulas, G. (2014)
      Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...

    • Article  

      Mutational profiling of the RAS, PI3K, MET and b-catenin pathways in cancer of unknown primary: a retrospective study of the Hellenic Cooperative Oncology Group 

      Pentheroudakis, George; Kotteas, E. A.; Kotoula, V.; Papadopoulou, K.; Charalambous, E.; Cervantes, A.; Ciuleanu, T.; Fountzilas, George; Pavlidis, Nicholas (2014)
      Cancer of unknown primary origin (CUP) had a poor prognosis, determined by clinico-histological characteristics, partly due to the lack of insights on its biology. We screened tumour DNA from 87 patients with CUP for CTNNB1 ...

    • Article  

      No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis 

      Bagos, Pantelis G.; Karnaouri, Anthi C.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J. (2007)
      We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies ...

    • Article  

      Targeting c-KIT, PDGFR in cancer of unknown primary: A screening study for molecular markers of benefit 

      Dova, L.; Pentheroudakis, George; Golfinopoulos, Vassilis; Malamou-Mitsi, Vassiliki D.; Georgiou, I.; Vartholomatos, G.; Ntemou, A.; Fountzilas, George; Pavlidis, Nicholas (2008)
      Aims: In view of available targeted therapies, we investigated the presence of c-kit, PDGFR gene mutations and protein expression in cancer of unknown primary (CUP) in order to study their contribution in pathogenesis, ...

    • Article  

      A twisted kiss: In vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer 

      Pentheroudakis, George; Kostadima, Lida; Dova, L.; Georgiou, I.; Tzavaras, T.; Vartholomatos, G.; Wirtz, R. M.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2010)
      KiSS-1 is a metastasis suppressor gene, its inactivation linked to advanced tumor stage and dismal prognosis. We studied its mutational status, transcription and protein expression in human cancer cell lines and patients ...

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