Browsing by Subject "Immunohistochemistry"

Article

Angiogenesis in cancer of unknown primary: Clinicopathological study of CD34, VEGF and TSP-1

Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Kalofonos, H. P.; Fountzilas, George; Fotsis, T.; Pavlidis, Nicholas (2005)

Background: Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge ...

Article

Apoptosis and hepatitis C virus infection in renal transplant recipients

Delladetsima, I.; Psichogiou, M.; Alexandrou, P.; Nikolopoulos, Georgios K.; Revenas, K.; Hatzakis, A.; Boletis, J. (2008)

Hepatocellular injury in renal transplant recipients with hepatitis C virus (HCV) infection remains unclear. The suppressed immune response, in combination with increased viremia levels, provides a unique setting for the ...

Article

Brain metastasis of unknown primary: A diagnostic and therapeutic dilemma

Polyzoidis, K. S.; Miliaras, G.; Pavlidis, Nicholas (2005)

The diagnosis of a brain metastasis is usually made during the routine follow up examinations of patients with known cancer, who are under the care of oncology departments. The involvement of the neurosurgeon depends on ...

Article

Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer

Economopoulou, P.; Mountzios, G.; Pavlidis, Nicholas; Pentheroudakis, George (2015)

Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis of metastatic malignancy in the absence of an identifiable primary site after diagnostic work up. CUP may either resemble a specific ...

Article

Cancer of unknown primary site

Pavlidis, Nicholas; Pentheroudakis, George (2012)

Cancer of unknown primary site (CUP) is a well recognised clinical disorder, accounting for 3-5 of all malignant epithelial tumours. CUP is clinically characterised as an aggressive disease with early dissemination. ...

Article

Cancer of unknown primary site: 20 questions to be answered

Pavlidis, Nicholas; Pentheroudakis, George (2010)

Cancer of unknown primary (CUP) is a common, well-recognized and heterogeneous clinical syndrome. Patients with CUP present with metastatic disease in the absence of an identifiable primary tumour despite a diagnostic ...

Article

Cancer of unknown primary: Biological and clinical characteristics

Pavlidis, Nicholas (2003)

Article

Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up

Fizazi, K.; Greco, F. A.; Pavlidis, Nicholas; Pentheroudakis, George (2011)

Article

Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up

Pavlidis, Nicholas; Briassoulis, E. Ch; Pentheroudakis, George (2010)

Article

Cancers of unknown primary site: ESMO clinical recommendation for diagnosis, treatment and follow-up

Briassoulis, E. Ch; Pavlidis, Nicholas; Felip, E. (2008)

Article

Cancers of unknown primary site: ESMO clinical recommendations for diagnosis, treatment and follow-up

Briassoulis, E. Ch; Pavlidis, Nicholas; Felip, E. (2009)

Article

Cancers of unknown primary site: ESMO Clinical Recommendations for diagnosis, treatment and follow-up

Briassoulis, E. Ch; Pavlidis, Nicholas (2007)

Article

The clinical significance of bcl-2 overexpression in breast cancer patients - A retrospective study with long term follow up

Bai, M. C.; Agnantis, Niki J.; Zagorianakou, P.; Kamina, S.; Nonni, A. V.; Pavlidis, Nicholas; Briassoulis, E. Ch (2001)

We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. In 38.3% of the cases ...

Article

Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma

Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Pavlidis, Nicholas (2006)

The aim of the study was to investigate angiogenesis in patients with advanced-stage ovarian carcinoma. We used paraffin-embedded tumor tissues from 33 patients diagnosed with FIGO III ovarian cancer who had optimal surgery ...

Article

Clinicopathological study of metallothionein immunohistochemical expression, in benign, borderline and malignant ovarian epithelial tumors

Zagorianakou, N.; Stefanou, D. G.; Makrydimas, G.; Zagorianakou, P.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2006)

Metallothioneins (MTs) are a family of cystein-rich metal-binding proteins, which are expressed in normal cells during fetal and postnatal life but also in a variety of human neoplasms. MT expression in human tumors has ...

Article

Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer

Ioachim, E.; Tsanou, E.; Briassoulis, E. Ch; Batsis, Ch; Karavasilis, V.; Charchanti, A.; Pavlidis, Nicholas; Agnantis, Niki J. (2003)

Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. Archived material of ...

Article

Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. Correlation with extracellular matrix components

Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Charchanti, A.; Damala, K.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)

Syndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction ...

Article

Computer-aided classification of breast cancer nuclei

Schnorrenberg, F.; Pattichis, Constantinos S.; Schizas, Christos N.; Kyriacou, Kyriacos C.; Vassiliou, M. (1996)

Breast cancer is the most common malignancy affecting the female population in industrialized countries. Prognostic factors, such as steroid receptors visualized in biopsy slides, provide critical information to oncologists ...

Article

DCC and TS protein expression in resected gastric cancer: A Hellenic Cooperative Oncology Group Study

Bamias, A. T.; Fountzilas, George; Michael, M. C.; Konstantaras, C.; Vrettou, E.; Eleftheriadis, E.; Papakostas, P.; Papadimitriou, K.; Pavlidis, Nicholas; Xiros, N.; Bai, M. C. (2008)

There is a high risk of relapse after resection of gastric cancer. We studied the prognostic significance of the deleted colorectal cancer (DCC) gene and thymidylate synthase (TS) protein expression after resection of ...

Article

Diagnostic and therapeutic management of cancer of an unknown primary

Pavlidis, Nicholas; Briassoulis, E. Ch; Hainsworth, J.; Greco, F. A. (2003)

Metastatic Cancer of Unknown Primary Site (CUP) accounts for approximately 3% of all malignant neoplasms and is therefore one of the 10 most frequent cancer diagnoses in man. Patients with CUP present with metastatic disease ...