The clinical significance of bcl-2 overexpression in breast cancer patients - A retrospective study with long term follow up
Date
2001Author
Bai, M. C.Agnantis, Niki J.
Zagorianakou, P.
Kamina, S.
Nonni, A. V.

Briassoulis, E. Ch
Source
Electronic Journal of Pathology and HistologyVolume
7Issue
1Pages
94-98Google Scholar check
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We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. In 38.3% of the cases approximately all neoplastic cells were stained positive (complete expression). A strong impact of complete bcl-2 expression on the clinical outcome was identified (p=0.01). We consider this study as a new approach. There is evidence that the assessment of bcl-2 at the level of complete expression provides important prognostic information for breast carcinoma patients treated surgically.