Browsing by Subject "Kinetics"

Article

Altered Phosphorylation, Biosynthesis and Degradation of the 170 kDa Isoform of Topoisomerase II in Amsacrine-Resistant Human Leukemia Cells

Ganapathi, R.; Zwelling, L.; Constantinou, Andreas I.; Ford, J.; Grabowski, D. (1993)

Resistance to amsacrine in HL-60/AMSA is 50-100 fold compared to the parental HL-60/S cells. Synthesis and phosphorylation of topoisomerase II (TOPO II) were 2-3 fold lower in HL-60/AMSA compared to HL-60/S cells metabolically ...

Article

The ASBM-SA turbulence closure: Taking advantage of structure-based modeling in current engineering CFD codes

Panagiotou, C. F.; Kassinos, Stavros C.; Aupoix, B. (2015)

Structure-based turbulence models (SBM) carry information about the turbulence structure that is needed for the prediction of complex non-equilibrium flows. SBM have been successfully used to predict a number of canonical ...

Article

Biological charge transfer via flickering resonance

Zhang, Y.; Liu, C.; Balaeff, A.; Skourtis, Spiros S.; Beratan, David N. (2014)

Biological electron-transfer (ET) reactions are typically described in the framework of coherent two-state electron tunneling or multistep hopping. However, these ET reactions may involve multiple redox cofactors in van ...

Article

Carbon nanotube-reinforced crosslinked polyethylene pipes for geothermal applications: From synthesis to decomposition using analytical pyrolysis-GC/MS and thermogravimetric analysis

Roumeli, E.; Markoulis, A.; Kyratsi, Theodora; Bikiaris, D.; Chrissafis, K. (2014)

Carbon nanotube reinforced crosslinked high density polyethylene (PEX) nanocomposites were synthesized for geothermal applications requiring higher polymer thermal conductivity and a comprehensive thermal decomposition ...

Article

Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase IIα phosphorylation

Constantinou, Andreas I.; Vaughan, A. T. M.; Yamasaki, H.; Kamath, N. (1996)

To explore the program of cell differentiation in Friend murine erythroleukemia (MEL) cells, we used three clonal variants: phorbol 12- myristate 13-acetate (PMA)-hypersensitive TS-19-101, PMA-resistant TR19-9, and ...

Article

The contribution of active and inactive structures to the statistics of a turbulent pipe flow

Stylianou, F. S.; Kassinos, Stavros C. (2017)

The current study is a short follow-up to our most recent work (Stylianou et al., 2016), where among other things we have presented an effective criterion suitable for distinguishing large-scale coherent structures with ...

Article

Copper(II) removal from aqueous solutions by adsorption on non-treated and chemically modified cactus fibres

Prodromou, Melpomeni; Pashalidis, Ioannis (2013)

The adsorption efficiency of a biomass by-product (cactus fibres) regarding the removal of copper(II) from aqueous solutions has been investigated before and after its chemical treatment. The chemical treatment of the ...

Article

Developing and investigating a pure Monte-Carlo module for transient neutron transport analysis

Mylonakis, A. G.; Varvayanni, M.; Grigoriadis, D. G. E.; Catsaros, N. (2017)

In the field of computational reactor physics, Monte-Carlo methodology is extensively used in the analysis of static problems while the transient behavior of the reactor core is mostly analyzed using deterministic algorithms. ...

Article

The effect of La3+-doping of CeO2 support on the water-gas shift reaction mechanism and kinetics over Pt/Ce1-xLaxO2-δ

Kalamaras, Christos M.; Petallidou, Klito C.; Efstathiou, Angelos M. (2013)

Platinum nanoparticles (dPt=1.0-1.2nm) supported on single CeO2 and La2O3 metal oxides and Ce0.8La0.2O2-δ solid solution were prepared to investigate for the first time the effect of La3+-doping of ceria on important ...

Article

The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells

Constantinou, Andreas I.; Grdina, D.; Kiguchi, K.; Huberman, E. (1992)

Treatment of human K-562-J leukemia cells for 1 h with the topoisomerase II-reactive drugs VP-16, VM-26, or mAMSA resulted in a dose-dependent inhibition of proliferation and in an increase in the percentage of cells ...

Article

Experimental and theoretical studies on physico-chemical parameters affecting the solubility of phosphogypsum

Papanicolaou, F.; Antoniou, Stella; Pashalidis, Ioannis (2009)

Phosphogypsum is a waste by-product of the phosphate fertilizer industry, which is usually disposed in the environment because of its restricted use in industrial applications. Physico-chemical conditions existing in stack ...

Article

Fabrication, characterization, and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l -lactide) electrospun membranes

Savva, I.; Odysseos, A. D.; Evaggelou, L.; Marinica, O.; Vasile, E.; Vekas, L.; Sarigiannis, Y.; Krasia-Christoforou, T. (2013)

The fabrication of electrospun magnetoactive fibrous nanocomposite membranes based on the water-soluble and biocompatible poly(ethylene oxide) (PEO), the biocompatible and biodegradable poly(l-lactide) (PLLA) and preformed ...

Article

Genotyping HIV-1 and HCV strains by a combinatorial DNA melting assay (COMA)

Kostrikis, Leontios G.; Shin, S.; Ho, David D. (1998)

Background: Human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) strains can be genetically classified into genetic lineages known as genetic types of subtypes according to phylogenetic analyses of ...

Article

Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors

Benltifa, Mahmoud; Hayes, Joseph M.; Vidal, Sébastien; Gueyrard, David; Goekjian, Peter G.; Praly, Jean Pierre; Kizilis, Gregory; Tiraidis, Costas; Alexacou, Kyra Melinda; Chrysina, Evangelia D.; Zographos, Spyros E.; Leonidas, Demetres D.; Archontis, Georgios Z.; Oikonomakos, Nikos G. (2009)

A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio- and stereoselective [3+2]-cycloaddition between the methylene acetylated exo-glucal and aromatic nitrile oxides. The deprotected cycloadducts ...

Article

Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues

Archontis, Georgios Z.; Watson, K. A.; Xie, Q.; Andreou, Georgia; Chrysina, Evangelia D.; Zographos, Spyros E.; Oikonomakos, Nikos G.; Karplus, M. (2005)

GP catalyzes the phosphorylation of glycogen to Glc-1-P. Because of its fundamental role in the metabolism of glycogen, GP has been the target for a systematic structure-assisted design of inhibitory compounds, which could ...

Article

Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

Oppedisano, F.; Catto, M.; Koutentis, Panayiotis Andreas; Nicolotti, O.; Pochini, L.; Koyioni, Maria G.; Introcaso, A.; Michaelidou, Sophia S.; Carotti, A.; Indiveri, C. (2012)

The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. A library of 1,2,3-dithiazoles was designed, synthesized and evaluated ...

Article

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H.; Collado, M.; Villasante, A.; Strati, K.; Ortega, S.; Cãamero, M.; Blasco, M. A.; Serrano, M. (2009)

The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...

Article

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Watson, K. A.; Chrysina, Evangelia D.; Tsitsanou, K. E.; Zographos, Spyros E.; Archontis, Georgios Z.; Fleet, G. W. J.; Oikonomakos, Nikos G. (2005)

Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-β-D-glucopyranosylamine have been identified ...

Article

The kinetics of T regulatory cells in shock: Beyond sepsis

Christaki, Eirini; Patrozou, E. (2010)

During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells ...

Article

Kinetics of UV-A/TiO2 photocatalytic degradation and mineralization of the antibiotic sulfamethoxazole in aqueous matrices

Xekoukoulotakis, Nikolaos P.; Drosou, C.; Brebou, C.; Chatzisymeon, Efthalia; Mantzavinos, D.; Hapeshi, E.; Fatta-Kassinos, Despo (2011)