Browsing by Subject "Mutation"
Now showing items 1-7 of 7
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Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target?
(2007)Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...
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The impact of iron overload and genotype on gonadal function in women with thalassaemia major
(2004)OBJECTIVE: The purpose of this study is to evaluate the impact of chronic iron overload and genotype on gonadal function in women with thalassaemia major.
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KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study
(2014)Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...
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Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009.
(2010)The article summarizes the expert discussion and recommendations on the use of molecular markers and of biological targeted therapies in metastatic colorectal cancer (mCRC), as well as a proposed treatment decision strategy ...
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Targeting c-KIT, PDGFR in cancer of unknown primary: A screening study for molecular markers of benefit
(2008)Aims: In view of available targeted therapies, we investigated the presence of c-kit, PDGFR gene mutations and protein expression in cancer of unknown primary (CUP) in order to study their contribution in pathogenesis, ...
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A twisted kiss: In vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer
(2010)KiSS-1 is a metastasis suppressor gene, its inactivation linked to advanced tumor stage and dismal prognosis. We studied its mutational status, transcription and protein expression in human cancer cell lines and patients ...