Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions
Ortiz, G. M.
Grant, R. M.
Miralles, G. D.
Kostrikis, Leontios G.
Bartlett, J. A.
Nixon, D. F.
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We report the emergence of drug-resistant viral mutations in chronically HIV-infected individuals undergoing structured treatment interruptions (STI). The protease mutation M46L and the reverse transcriptase mutations K101E and K103N were detected at the end of the second or third STI. We conclude that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.
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