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Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions

dc.contributor.authorSchweighardt, B.en
dc.contributor.authorOrtiz, G. M.en
dc.contributor.authorGrant, R. M.en
dc.contributor.authorWellons, M.en
dc.contributor.authorMiralles, G. D.en
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorBartlett, J. A.en
dc.contributor.authorNixon, D. F.en
dc.creatorSchweighardt, B.en
dc.creatorOrtiz, G. M.en
dc.creatorGrant, R. M.en
dc.creatorWellons, M.en
dc.creatorMiralles, G. D.en
dc.creatorKostrikis, Leontios G.en
dc.creatorBartlett, J. A.en
dc.creatorNixon, D. F.en
dc.date.accessioned2019-11-04T12:52:38Z
dc.date.available2019-11-04T12:52:38Z
dc.date.issued2002
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53373
dc.description.abstractWe report the emergence of drug-resistant viral mutations in chronically HIV-infected individuals undergoing structured treatment interruptions (STI). The protease mutation M46L and the reverse transcriptase mutations K101E and K103N were detected at the end of the second or third STI. We conclude that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.en
dc.sourceAIDSen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0037159928&doi=10.1097%2f00002030-200211220-00018&partnerID=40&md5=3729449c36298cdfb73a54dfc721feef
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectpriority journalen
dc.subjectDrug Administration Scheduleen
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectlamivudineen
dc.subjectintermethod comparisonen
dc.subjectcase reporten
dc.subjectHIV Infectionsen
dc.subjectnonhumanen
dc.subjecthighly active antiretroviral therapyen
dc.subjectvirus loaden
dc.subjectgene mutationen
dc.subjectMutationen
dc.subjectAnti-HIV Agentsen
dc.subjectHuman immunodeficiency virus 1en
dc.subjectindinaviren
dc.subjectHIV-1en
dc.subjectantiretrovirus agenten
dc.subjectRNA directed DNA polymeraseen
dc.subjectefavirenzen
dc.subjectnelfinaviren
dc.subjectvirus mutationen
dc.subjectstavudineen
dc.subjectgene identificationen
dc.subjectDrug Resistance, Viralen
dc.subjectproteinaseen
dc.subjectRNA, Viralen
dc.subjectDrug Therapy, Combinationen
dc.subjectvirus enzymeen
dc.titleEmergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptionsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1097/00002030-200211220-00018
dc.description.volume16
dc.description.startingpage2342
dc.description.endingpage2344
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :46</p>en
dc.source.abbreviationAIDSen
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]
dc.gnosis.orcid0000-0002-5340-7109


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