Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Submit Date

Article

An isolate of human immunodeficiency virus type 1 originally classified as subtype I represents a complex mosaic comprising three different group M subtypes (A, G, and I)

Gao, F.; Robertson, D. L.; Carruthers, C. D.; Li, Y.; Bailes, E.; Kostrikis, Leontios G.; Salminen, M. O.; Bibollet-Ruche, F.; Peeters, M.; Ho, David D.; Shaw, G. M.; Sharp, P. M.; Hahn, B. H. (1998)

Full-length reference clones and sequences are currently available for eight human immunodeficiency virus type 1 (HIV-1) group M subtypes (A through H), but none have been reported for subtypes I and J, which have only ...

Article

Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis

Georgiades, Pantelis; Brickell, P. M. (1997)

Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...

Article

Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development

Demetriou, Manolis C.; Stylianou, Panayiota; Andreou, Maria I.; Yiannikouri, Olga; Tsaprailis, George; Cress, Anne E.; Skourides, Paris A. (2008)

The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates ...

Article

Intestinal Stem Cells: A Decade of Intensive Research in Drosophila and the Road Ahead

Apidianakis, Yiorgos; Tamamouna, V.; Teloni, S.; Pitsouli, Chrysoula (2017)

Since the molecular characterization of Drosophila midgut progenitors in 2006, a few hundred articles studying fly intestinal stem cells have already been published. There was a relative lag phase in creating new knowledge ...

Article

Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

Article

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis

Petridou, Nicoletta I.; Skourides, Paris A. (2014)

Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...

Article

Hedgehog restricts its expression domain in the Drosophila wing

Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)

The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...

Article

Neural network controlling feeding in Lymnaea stagnalis: Immunocytochemical localization of myomodulin, small cardioactive peptide, buccalin, and FMRFamide- related peptides

Santama, Niovi; Brierley, M.; Burke, J. F.; Benjamin, P. R. (1994)

Article

Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells

Christodoulou, A.; Santarella-Mellwig, R.; Santama, Niovi; Mattaj, I. W. (2016)

Book Chapter

Overview of Polymer and Copolymer Materials for Organic Photovoltaics

Economopoulos, Solon P.; Itskos, Grigorios; Koutentis, Panayiotis Andreas; Choulis, Stelios A. (Wiley Blackwell, 2014)

Article

Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα

Aoyama, M.; Grabowski, D. R.; Dubyak, G. R.; Constantinou, Andreas I.; Rybicki, L. A.; Bukowski, R. M.; Ganapathi, M. K.; Hickson, I. D.; Ganapathi, R. (1998)

Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...

Article

A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis

Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)

FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...

Article

Intein-mediated site-specific conjugation of Quantum Dots to proteins in vivo

Charalambous, Anna; Andreou, Maria I.; Skourides, Paris A. (2009)

We describe an intein based method to site-specifically conjugate Quantum Dots (QDs) to target proteins in vivo. This approach allows the covalent conjugation of any nanostructure and/or nanodevice to any protein and thus ...

Article

Contrasting frequencies of CCR5Δ32 and CCR2-64I alleles in the Tunisian population [1]

Barbouche, R. M.; Hong, L.; Dellagi, K.; Kostrikis, Leontios G. (2001)

Article

Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression

Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Lau, G. W.; Baldini, R. L.; Davis, R. W.; Rahme, L. G. (2005)

Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...

Article

Neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis

Pavlopoulos, Elias; Pitsouli, Chrysoula; Klueg, K. M.; Muskavitch, M. A. T.; Moschonas, Nicholas K.; Delidakis, Christos (2001)

Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding ...

Article

Novobiocin- and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity

Constantinou, Andreas I.; Henning-Chubb, C.; Huberman, E. (1989)

Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or ...

Article