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Browsing by Subject "nonhuman"

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    • Article  

      1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study 

      Charalambous, Anna; Koyioni, Maria; Antoniades, Ioanna; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, L. S.; Rakitin, O. A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
      A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...

    • Article  

      40LoVe and Samba are involved in Xenopusneural development and functionally distinct from hnRNP AB 

      Andreou, Maria I.; Yan, C. Y. I.; Skourides, Paris A. (2014)
      Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a large group of modular RNA-binding proteins classified according to their conserved domains. This modular nature, coupled with a large choice of alternative ...

    • Article  

      A ligand-independent integrin β1 mechanosensory complex guides spindle orientation 

      Petridou, Nicoletta I.; Skourides, Paris A. (2016)
      Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...

    • Article  

      Activated biochar derived from cactus fibres - Preparation, characterization and application on Cu(II) removal from aqueous solutions 

      Hadjittofi, Loukia; Prodromou, Melpomeni; Pashalidis, Ioannis (2014)
      The adsorption efficiency of activated biochar prepared from cactus fibres regarding the removal of Cu(II) from aqueous solutions has been investigated as a function of various physicochemical parameters (e.g. pH, initial ...

    • Article  

      Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel S.; Guan, Junlin; Skourides, Paris A. (2012)
      Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...

    • Article  

      Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells 

      Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)
      We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...

    • Article  

      Alport syndrome from bench to bedside: The potential of current treatment beyond RAAS blockade and the horizon of future therapies 

      Gross, O.; Perin, L.; Constantinou-Deltas, Constantinos D. (2014)
      The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable'. Today, RAAS blockade has changed the ...

    • Article  

      Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance 

      Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos C.; Kostrikis, Leontios G. (2009)
      This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine ...

    • Article  

      Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance 

      Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos C.; Kostrikis, Leontios G. (2009)
      This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine ...

    • Article  

      Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance 

      Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos C.; Kostrikis, Leondios G. (2009)
      This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine ...

    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

    • Article  

      Architectural insight into inovirus-associated vectors (IAVs) and development of IAV-based vaccines inducing humoral and cellular responses: Implications in HIV-1 vaccines 

      Hassapis, K. A.; Stylianou, Dora C.; Kostrikis, Leontios G. (2014)
      Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor ...

    • Article  

      Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation 

      Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Vermeulen, M.; Mann, M.; Bähler, J.; Green, R. D.; Kouzarides, T. (2007)
      Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...

    • Article  

      Automated species recognition of antbirds in a Mexican rainforest using hidden Markov models 

      Trifa, V. M.; Kirschel, A. N. G.; Taylor, C. E.; Vallejo, E. E. (2008)
      Behavioral and ecological studies would benefit from the ability to automatically identify species from acoustic recordings. The work presented in this article explores the ability of hidden Markov models to distinguish ...

    • Article  

      Autosomal dominant polycystic kidney disease: Molecular genetics and molecular pathogenesis 

      Koptides, Michael; Constantinou-Deltas, Constantinos D. (2000)
      Mutations in three different genes, PKD1, PKD2 and PKD3, can cause a very similar clinical picture of the autosomal dominant form of polycystic kidney disease (ADPKD). Apparently, mutations in the PKD3 gene, which is still ...

    • Article  

      Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer 

      Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)
      Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

    • Article  

      The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies 

      Kapsetaki, Stefania Elisavet; Tzelepis, Ilias; Avgousti, Kalodoti; Livadaras, Ioannis; Garantonakis, Nikos G.; Varikou, Kyriaki N.; Apidianakis, Yiorgos (2014)
      Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by ...

    • Article  

      Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo(α) pyrene-induced leiomyosarcomas in wistar rats 

      Liasko, Roman; Kabanos, Themistoklis A.; Karkabounas, Spyridon Ch; Malamas, Michael Ph; Tasiopoulos, Anastasios J.; Stefanou, Dimitrios G.; Collery, P.; Evangelou, Angelos M. (1998)
      Background: Vanadium is a potent environmental and body metal, possessing remarkable antitumor and antidiabetic properties. Vanadium salts and complexes have been widely investigated for their anticarcinogenic properties ...

    • Article  

      Benefits of vascular normalization are dose and time dependent - Letter 

      Huang, Y.; Stylianopoulos, T.; Duda, D. G.; Fukumura, D.; Jain, R. K. (2013)

    • Article  

      C2, An Unusual Filamentous Bacterial Virus: Protein Sequence and Conformation, DNA Size and Conformation, and Nucleotide/Subunit Ratio 

      Kostrikis, Leontios G.; Reisberg, S. A.; Day, L. A.; Kim, H. -Y; Shin, S. (1995)
      Inovirus C2 is 1295 nm long and 6.8 nm in diameter, and its mass is 24 million Da. Its genome is a topologically circular, single-stranded DNA molecule of 8100 nucleotides. The DNA is packed in the virion as two antiparallel ...

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