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Browsing by Subject "Neoplasm"

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    • Article  

      Cancer and pregnancy: A comprehensive review 

      Voulgaris, E.; Pentheroudakis, George; Pavlidis, Nicholas (2011)
      Background: Pregnancy complicated by cancer is relatively rare but, as women in western societies tend to delay childbearing to the third and fourth decade of life, this phenomenon is going to be encountered more often in ...

    • Article  

      Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer? 

      Pavlidis, Nicholas (2011)
      The incidence of cancer during pregnancy is a rare phenomenon and is estimated to occur in 1:1000 pregnancies. This co-existence is likely to rise since the delay of childbearing to the later reproductive age is nowadays ...

    • Article  

      Cancer treatment reviews welcomes submission of the Cochrane Reviews 

      Pavlidis, Nicholas; Stahel, R. A.; Clarke, M.; Djulbegovic, B. (2006)

    • Article  

      Cavitating squamous cell lung carcinoma-distinct entity or not? Analysis of radiologic, histologic, and clinical features 

      Pentheroudakis, George; Kostadima, Lida; Fountzilas, George; Kalogera-Fountzila, Anna; Klouvas, G. D.; Kalofonos, H. P.; Pavlidis, Nicholas (2004)
      Introduction: Patients with cavitating squamous lung carcinoma (cSLC) are believed to harbor aggressive, chemoresistant disease with distinct features and fare poorly. We retrospectively analyzed radiologic, histologic, ...

    • Article  

      Clinical value of CA 15-3, mucin-like carcinoma-associated antigen, tumor polypeptide antigen, and carcinoembryonic antigen in monitoring early breast cancer patients 

      Pectasides, Dimitrios; Pavlidis, Nicholas; Gogou, L.; Antoniou, F.; Nikolaides, C.; Tsikalakis, D.; Fountzilas, George (1996)
      A total of 209 postsurgical breast cancer patients were prospectively monitored with simultaneous serum level estimations of CA 15-3, mucin-like carcinoma-associated antigen (MCA), tumor polypeptide antigen (TPA), and ...

    • Article  

      The current and future role of the medical oncologist in the professional care for cancer patients: A position paper by the European Society for Medical Oncology (ESMO) 

      Popescu, R. A.; Schäfer, R.; Califano, R.; Eckert, R.; Coleman, R.; Douillard, J.-Y.; Cervantes, A.; Casali, Paolo G.; Sessa, Cristiana; Cutsem, E. van; Vries, Elisabeth G. E. de; Pavlidis, Nicholas; Fumasoli, K.; Wörmann, B.; Samonigg, H.; Cascinu, S.; Hernández, J. J. C.; Howard, A. J.; Ciardiello, F.; Stahel, R. A.; Piccart, M. (2014)
      The number of cancer patients in Europe is rising and significant advances in basic and applied cancer research are making the provision of optimal care more challenging. The concept of cancer as a systemic, highly ...

    • Article  

      Depression in cancer: The many biobehavioral pathways driving tumor progression 

      Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)
      Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...

    • Article  

      Diagnostic and therapeutic management of cancer of an unknown primary 

      Pavlidis, Nicholas; Briassoulis, E. Ch; Hainsworth, J.; Greco, F. A. (2003)
      Metastatic Cancer of Unknown Primary Site (CUP) accounts for approximately 3% of all malignant neoplasms and is therefore one of the 10 most frequent cancer diagnoses in man. Patients with CUP present with metastatic disease ...

    • Article  

      Docetaxel and gemcitabine in anthracycline-resistant advanced breast cancer: A hellenic cooperative oncology group phase II study 

      Fountzilas, George; Nikolaides, C.; Bafaloukos, Dimitrios; Kalogera-Fountzila, Anna; Kalofonos, H. P.; Samelis, G.; Aravantinos, Gerasimos; Pavlidis, Nicholas (2000)
      A phase II study was conducted to evaluate the activity and toxicity profile of the combination of docetaxel and gemcitabine in anthracycline- resistant advanced breast cancer (ABC). Thirty-nine eligible patients with a ...

    • Article  

      Donor-derived breast cancer in a bone marrow transplantation recipient 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Kamakari, S.; Metaxa-Mariatou, V.; Pavlidis, Nicholas (2009)
      We present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified ...

    • Article  

      Efficacy and safety of more intensive lowering of LDL cholesterol [1] 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2011)

    • Article  

      Evaluation of six tumor markers in patients with carcinoma of unknown primary 

      Pavlidis, Nicholas; Kalef-Ezra, J. A.; Briassoulis, E. Ch; Skarlos, Dimosthenis V.; Kosmidis, Paraskevas A.; Saferiadis, K.; Bairaktari, Eleni Th; Bafaloukos, Dimitrios; Maravegias, A.; Theoharis, D.; Fountzilas, George (1994)
      We have retrospectively evaluated six serum tumor markers in 85 patients with carcinoma of unknown primary. The serum levels of carcinoembryonic antigen (CEA), CA 19‐9, CA 15‐3, CA 125, β‐chorionic gonadotropin (β‐HCG) and ...

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Gemcitabine and vinorelbine as second-line treatment in patients with metastatic breast cancer progressing after first-line taxane-based chemotherapy: A phase II study conducted by the Hellenic Cooperative Oncology Group 

      Nikolaides, C.; Dimopoulos, M. A.; Samantas, E.; Bafaloukos, Dimitrios; Kalofonos, H. P.; Fountzilas, George; Razi, E. D.; Kosmidis, Paraskevas A.; Pavlidis, Nicholas (2000)
      Background: Gemcitabine and vinorelbine have shown activity in breast cancer. A phase II trial was initiated in order to evaluate the response rate (RR) and time to progression (TTP) of the combination of the two drugs in ...

    • Article  

      Gemcitabine plus pegylated liposomal doxorubicin in patients with advanced epithelial ovarian cancer resistant/refractory to platinum and/or taxanes. A HeCOG phase II study 

      Skarlos, Dimosthenis V.; Kalofonos, H. P.; Fountzilas, George; Dimopoulos, M. A.; Pavlidis, Nicholas; Razi, E. D.; Economopoulos, T.; Pectasides, Dimitrios; Gogas, H.; Kosmidis, Paraskevas A.; Bafaloukos, Dimitrios; Klouvas, G. D.; Kyratzis, G.; Aravantinos, Gerasimos (2005)
      Background: A phase II study was conducted to evaluate the efficacy and toxicity of the combination of gemcitabine (GEM) and pegylated liposomal doxorubicin (PLD) in patients with platinum- and/or taxane-resistant/refractory ...

    • Article  

      Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target? 

      Dova, L.; Pentheroudakis, George; Georgiou, I.; Malamou-Mitsi, Vassiliki D.; Vartholomatos, G.; Fountzilas, George; Kolaitis, N.; Kitsou, E.; Pavlidis, Nicholas (2007)
      Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...

    • Article  

      High levels of topoisomerase IIα protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment 

      Pentheroudakis, George; Goussia, Anna; Voulgaris, E.; Nikolaides, C.; Ioannidou, E.; Papoudou-Bai, A.; Grepi, K.; Kanavaros, P.; Pavlidis, Nicholas; Bai, M. C. (2010)
      Gene copy number and protein expression of topoisomerase IIα were correlated to benefit from anthracyclines in various tumors. A retrospective series of 69 patients with DLBCL managed with CHOP chemotherapy were studied ...

    • Article  

      Ifosfamide plus oral etoposide salvage chemotherapy for platinum- resistant paclitaxel-pretreated ovarian cancer 

      Aravantinos, Gerasimos; Dimopoulos, M. A.; Kosmidis, Paraskevas A.; Bafaloukos, Dimitrios; Papadimitriou, C.; Kiamouris, Ch; Pavlidis, Nicholas; Sikiotis, K.; Papakostas, P.; Skarlos, Dimosthenis V. (2000)
      Background: The prognosis of platinum resistant ovarian cancer is very poor and the treatment of choice has not been clearly defined. Patients and methods: We conducted a phase II study with the combination of ifosfamide ...

    • Article  

      «Juvenile» oncology - A missing subspecialty. The experience of a reference cancer centre 

      Pentheroudakis, George; Mauri, D.; Kostadima, Lida; Golfinopoulos, Vassilis; Alexiou, G.; Karakatsanis, A.; Pavlidis, Nicholas (2006)
      Introduction: Despite unique tumor epidemiology and a higher cancer incidence compared to pediatric patients, adolescents and young adults have not been receiving specialized, multidisciplinary, centralized care. In an ...

    • Article  

      Metastatic involvement of placenta and foetus in pregnant women with cancer. 

      Pavlidis, Nicholas; Pentheroudakis, George (2008)

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