• Article  

      The beginning of personalized medicine in sepsis: Small steps to a bright future 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...
    • Article  

      Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis 

      Bonovas, Stefanos; Fiorino, Gionata; Allocca, Mariangela; Lytras, Theodoros; Nikolopoulos, Georgios K.; Peyrin-Biroulet, L.; Danese, Silvio (2016)
      Background & Aims Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether biologic agents affect ...
    • Article  

      Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer 

      Economopoulou, P.; Mountzios, G.; Pavlidis, Nicholas; Pentheroudakis, George (2015)
      Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis of metastatic malignancy in the absence of an identifiable primary site after diagnostic work up. CUP may either resemble a specific ...
    • Article  

      Cost-effectiveness of leucoreduction for prevention of febrile non-haemolytic transfusion reactions 

      Tsantes, Argirio E.; Kyriakou, Elias; Nikolopoulos, Georgios K.; Stylos, D.; Sidhom, M.; Bonovas, Stefanos; Douramani, Panagiota; Kalantzis, Dimitrios; Kokoris, Styliani; Valsami, S.; Stamoulis, K.; Politou, M.; Foudoulaki-Paparizos, Leontini (2014)
      Background. The cost-effectiveness of universal leucoreduction of blood components remains unclear. When using leucoreduced red blood cells, the decrease in the rate of febrile non-haemolytic transfusion reactions (FNHTR) ...
    • Article  

      Enhanced HIV-1 surveillance using molecular epidemiology to study and monitor HIV-1 outbreaks among intravenous drug users (IDUs) in Athens and Bucharest 

      Paraskeva, D.; Paraschiv, S.; Sypsa, V.; Nikolopoulos, Georgios K.; Tsiara, Chrissa G.; Magiorkinis, Gkikas; Psichogiou, M.; Flampouris, Andreas; Mardarescu, Mariana; Niculescu, I.; Batan, Ionelia; Malliori-Minerva, Melpomeni; Otelea, D.; Hatzakis, A. (2015)
      Background: A significant increase in HIV-1 diagnoses was reported among Injecting Drug Users (IDUs) in the Athens (17-fold) and Bucharest (9-fold) metropolitan areas starting 2011. Methods: Molecular analyses were conducted ...
    • Article  

      Estimating HIV incidence and number of undiagnosed individuals living with HIV in the European union/ European economic area, 2015 

      Pharris, Anastasia; Quinten, C.; Noori, T.; Amato-Gauci, A. J.; Sighem, A. van; Schmid, D.; Rueckerl, I.; Zangerle, R.; Sasse, A.; Beckhoven, D. van; Denauw, F.; Varleva, T.; Georgieva, V.; Blazic, T. N.; Pavlic, J.; Begovac, J.; Koliou, M.; Hadjihannas, L.; Demetriou, A.; Maly, M.; Šikolová, V.; Cowan, Susan; Fouchard, J.; Rüütel, K.; Pääsukene, A. L.; Liitsola, K.; Salminen, M.; Brummer-Korvenkontio, H.; Cazein, F.; Pillonel, J.; Lot, F.; Comboroure, J.-C.; Gunsenheimer-Bartmeyer, Barbara; Heiden, M. A. Der; Kupfer, G.; Marcus, U.; Nikolopoulos, Georgios K.; Paraskeva, D.; Konte, Vasileia; Dudas, M.; Szalay, K.; Briem, H.; Sigmundsdottir, G.; Igoe, D.; O’Donnell, K.; Hurley, C.; Lyons, F.; Suligoi, B.; Caraglia, A.; Konova, S.; Erne, S.; Caplinskiene, I.; Fischer, A.; Hoffmann, P.; Melillo, J. M.; Melillo, T.; Coul, Eline Op de; David, S.; Blystad, H.; Myrberg, A. J.; Rosinska, M.; Wawer, I.; Mansinho, K.; Martins, H. C.; Melillo, T.; Mardarescu, Mariana; Truska, P.; Mikas, J.; Klavs, I.; Diaz, Alejandro; Nuñez, O.; Castillo, O.; Avdicova, Maria; Sonnerborg, A.; Kirwan, P.; Chau, C.; Okala, S.; Brown, A.; Delpech, Valerie (2016)
      Since 2011, human immunodeficiency virus (HIV) incidence appears unchanged in the European Union/ European Economic Area with between 29,000 and 33,000 new cases reported annually up to 2015. Despite evidence that HIV ...
    • Article  

      Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece 

      Nikolopoulos, Georgios K.; Katsoulidou, Antigoni; Kantzanou, Maria; Rokka, C.; Tsiara, Chrissa G.; Sypsa, V.; Paraskeva, D.; Psichogiou, M.; Friedman, Samuel R.; Hatzakis, A. (2017)
      This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical ...
    • Article  

      KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study 

      Negru, S.; Papadopoulou, E.; Apessos, A.; Stanculeanu, D. L.; Ciuleanu, E.; Volovat, C.; Croitoru, A.; Kakolyris, S.; Aravantinos, Gerasimos; Ziras, N.; Athanasiadis, E.; Touroutoglou, N.; Pavlidis, Nicholas; Kalofonos, H. P.; Nasioulas, G. (2014)
      Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...
    • Article  

      New technologies in predicting, preventing and controlling emerging infectious diseases 

      Christaki, Eirini (2015)
      Surveillance of emerging infectious diseases is vital for the early identification of public health threats. Emergence of novel infections is linked to human factors such as population density, travel and trade and ecological ...
    • Article  

      Probing the unknown in cancer of unknown primary: Which way is the right way? 

      Pentheroudakis, George; Pavlidis, Nicholas (2010)
    • Article  

      Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper 

      Casali, Paolo G.; Bruzzi, P.; Bogaerts, Jan; Blay, Jean-Yves; Aapro, M. S.; Adamou, A.; Berruti, A.; Bressington, J.; Bruzzi, B.; Capocaccia, R.; Cardoso, Fatima; Celis, J. E.; Cervantes, A.; Ciardiello, F.; Claussen, C.; Coleman, M.; Comis, S.; Craine, S.; Boltz, D. De; Lorenzo, F. De; P, Angelo Dei Tos; Gatta, G.; Geissler, J.; Giuliani, R.; Grande, E.; Gronchi, A.; Jezdic, S.; Jonsson, B.; Jost, Lorenz M.; Keulen, H.; Lacombe, D.; Lamory, G.; Cam, Y. Le; Priolo, S. Leto di; Licitra, Lisa; Macchia, F.; Margulies, A.; Marreaud, S.; McVie, G.; Narbutas, S.; Oliver, K.; Pavlidis, Nicholas; Pelouchova, J.; Pentheroudakis, George; Piccart, M.; Pierotti, M. A.; Pravettoni, G.; Redmond, K.; Riegman, P.; Ruffilli, M. P.; Ryner, D.; Sandrucci, S.; Seymour, M.; Torri, V.; Trama, A.; Belle, S. Van; Vassal, G.; Wartenberg, M.; Watts, C.; Wilson, A.; Yared, W. (2015)
      While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. ...