Browsing by Subject "Single nucleotide polymorphism"
Now showing items 1-9 of 9
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Article
Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group study
(2012)Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T ...
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The beginning of personalized medicine in sepsis: Small steps to a bright future
(2014)There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...
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The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host
(2014)Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...
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Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls
(2011)Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...
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The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis
(2010)Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...
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The effect of plasma homocysteine levels on clinical outcomes of patients with acute lung injury/acute respiratory distress syndrome
(2009)Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important ...
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Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis
(2007)Introduction: Platelet adhesion to fibrillar collagen via the membrane glycoprotein (GP) Ia/IIa (α2β1), is a crucial event in the pathogenesis of arterial occlusive disorders. The C807T single nucleotide polymorphism of ...
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Meta-analysis of family-based and case-control genetic association studies that use the same cases
(2011)In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ...
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Personalized medicine in sepsis: The coming of age
(2013)"a there is both the need to discover specific and clinically useful biomarkers in order to diagnose sepsis, define the hosta s immune status, monitor treatment and define prognosis and to develop medications that would ...