Browsing by Subject "Tumors"
Now showing items 1-20 of 24
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Article
Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components
(2016)Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification ...
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Article
Biphasic modeling of brain tumor biomechanics and response to radiation treatment
(2016)Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
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Article
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
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Article
Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies
(2011)Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
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Article
Design considerations for nanotherapeutics in oncology
(2015)Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...
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Conference Object
Design rules for cancer nanomedicines
(Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...
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Conference Object
The effect of color correction of endoscopy images for quantitative analysis in endometrium
(2005)The objective of this study was to develop a standardized protocol for the capturing and analysis of endoscopy digital images for subsequent use in a Computer Aided Diagnosis (CAD) system in gynaecological cancer. Images ...
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Article
Evolution of osmotic pressure in solid tumors
(2014)The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...
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Conference Object
In vivo imaging of microvasculature using optical coherence tomography
(Correspondence Address: Vakoc, B. J., 2010)In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which ...
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Article
Intelligent drug delivery systems for the treatment of solid tumors
(2016)The rationale for the use of nanoparticle formulations to treat cancer is based on the ability of these particles to facilitate selective delivery of drugs to the tumor site, reducing adverse effects and improving therapeutic ...
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Conference Object
Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors
(Springer Verlag, 2016)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Doctoral Thesis Open Access
The mechanics of brain tissue in pathological conditions
(Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering, 2017-12)Οι μηχανικές τάσεις είναι κεντρικής σημασίας στην ανάπτυξη των όγκων στον εγκέφαλο και στην ανταπόκριση τους κατά τη θεραπεία, εφόσον αυτοί περιτριγυρίζονται από ιστούς με μεγάλη διαφοροποίηση των μηχανικών τους ιδιοτήτων. ...
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Article
Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
(2016)Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
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Article
Nanoscopic cationic methacrylate star homopolymers: Synthesis by group transfer polymerization, characterization and evaluation as transfection reagents
(2004)Seven star polymers with degrees of polymerization (DPs) of the arms from 10 to 100 and dimensions in the nanometer range were prepared using sequential group transfer polymerization of 2-(dimethylamino)-ethyl methacrylate ...
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Doctoral Thesis Open Access
The role of innate immunity and stress signalling pathways in intestinal proliferation, endoreplication and tumorigenesis
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-05)Ο ανεξέλεγκτος κυτταρικός πολλαπλασιασμός και ο πολλαπλασιασμός του DNA που δεν συνοδεύεται από κυτταρική διαίρεση έχουν περιγραφεί εκτενώς στα καρκινικά κύτταρα. Δεδομένου ότι και τα δύο προαναφερθέντα φαινόμενα προκαλούνται ...
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Article
The role of mechanical forces in tumor growth and therapy
(2014)Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
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Article
The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
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Article
Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
(2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Article
Solid Tumors Are Poroelastic Solids with a Chemo-mechanical Feedback on Growth
(2017)The experimental evidence that a feedback exists between growth and stress in tumors poses challenging questions. First, the rheological properties (the “constitutive equations”) of aggregates of malignant cells are still ...
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Article
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
(2017)Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...