• Article  

      Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components 

      Stylianou, A.; Stylianopoulos, T. (2016)
      Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification ...
    • Article  

      Biphasic modeling of brain tumor biomechanics and response to radiation treatment 

      Angeli, S.; Stylianopoulos, T. (2016)
      Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
    • Article  

      Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)
      Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...
    • Article  

      Design considerations for nanotherapeutics in oncology 

      Stylianopoulos, T.; Jain, R. K. (2015)
      Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...
    • Conference Object  

      Design rules for cancer nanomedicines 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)
      The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...
    • Article  

      Evolution of osmotic pressure in solid tumors 

      Voutouri, C.; Stylianopoulos, T. (2014)
      The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...
    • Conference Object  

      In vivo imaging of microvasculature using optical coherence tomography 

      Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (Correspondence Address: Vakoc, B. J., 2010)
      In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which ...
    • Article  

      Intelligent drug delivery systems for the treatment of solid tumors 

      Stylianopoulos, T. (2016)
      The rationale for the use of nanoparticle formulations to treat cancer is based on the ability of these particles to facilitate selective delivery of drugs to the tumor site, reducing adverse effects and improving therapeutic ...
    • Conference Object  

      Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (Springer Verlag, 2016)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
    • Doctoral Thesis  

      The mechanics of brain tissue in pathological conditions 

      Angeli, Stelios I. (Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering, 2017-12)
      Οι μηχανικές τάσεις είναι κεντρικής σημασίας στην ανάπτυξη των όγκων στον εγκέφαλο και στην ανταπόκριση τους κατά τη θεραπεία, εφόσον αυτοί περιτριγυρίζονται από ιστούς με μεγάλη διαφοροποίηση των μηχανικών τους ιδιοτήτων. ...
    • Article  

      Multiscale modelling of solid tumour growth: the effect of collagen micromechanics 

      Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)
      Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
    • Article  

      Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration 

      Kalli, M.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2018)
      Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
    • Article  

      Solid Tumors Are Poroelastic Solids with a Chemo-mechanical Feedback on Growth 

      Ambrosi, D.; Pezzuto, S.; Riccobelli, D.; Stylianopoulos, T.; Ciarletta, P. (2017)
      The experimental evidence that a feedback exists between growth and stress in tumors poses challenging questions. First, the rheological properties (the “constitutive equations”) of aggregates of malignant cells are still ...
    • Article  

      Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy 

      Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)
      Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
    • Article  

      Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...