Browsing by Subject "adult"

Article

Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells

Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)

We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...

Article

Alport syndrome from bench to bedside: The potential of current treatment beyond RAAS blockade and the horizon of future therapies

Gross, O.; Perin, L.; Constantinou-Deltas, Constantinos D. (2014)

The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable'. Today, RAAS blockade has changed the ...

Article

Analysis of expired air of fasting male monks at Mount Athos

Statheropoulos, Miltiades K.; Agapiou, Agapios; Georgiadou, A. (2006)

Expired air chemical analysis is investigated as a search and locate method for the early detection of entrapped people under the ruins of collapsed buildings after an earthquake. Fasting individuals were examined as a ...

Article

Assessment of the risk factors of coronary heart events based on data mining with decision trees

Karaolis, Minas A.; Moutiris, Joseph Antoniou; Hadjipanayi, Demetra; Pattichis, Constantinos S. (2010)

Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment ...

Article

Autosomal dominant medullary cystic kidney disease: Evidence of gene locus heterogeneity

Fuchshuber, A.; Constantinou-Deltas, Constantinos D.; Berthold, S.; Stavrou, Christoforos V.; Vollmer, M.; Burton, C.; Feest, T.; Krieter, D.; Gal, A.; Brandis, M.; Pierides, Alkis M.; Hildebrandt, F. (1998)

Autosomal dominant medullary cystic kidney disease (ADMCKD

Article

Autosomal dominant polycystic kidney disease - Type 2. Ultrasound, genetic and clinical correlations

Demetriou, Kyproula; Tziakouri, Chrysa H.; Anninou, Kristiana; Eleftheriou, Andri; Koptides, Michael; Nicolaou, Alexia; Constantinou-Deltas, Constantinos D.; Pierides, Alkis M. (2000)

Background. Ultrasound, genetic and clinical correlations are available for ADPKD-1, but lacking for ADPKD-2. The present study was carried out to address: (i) the age-related diagnostic usefulness of ultrasound compared ...

Article

Autosomal-dominant medullary cystic kidney disease type 1: Clinical and molecular findings in six large Cypriot families

Stavrou, Christoforos V.; Koptides, Michael; Tombazos, C.; Psara, E.; Patsias, Charalambos; Zouvani, Ioanna; Kyriacou, Kyriacos C.; Hildebrandt, F.; Christofides, Tasos C.; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2002)

Background. Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, ...

Article

Autosomal-dominant medullary cystic kidney disease type 1: Clinical and molecular findings in six large Cypriot familiesAAA

Stavrou, Christoforos V.; Koptides, Michael; Tombazos, C.; Psara, E.; Patsias, Charalambos; Zouvani, Ioanna; Kyriacou, Kyriacos C.; Hildebrandt, F.; Christofides, Tasos C.; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2002)

Background. Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, ...

Article

CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: Association with increased 2-year maternal mortality

John, G. C.; Bird, T.; Overbaugh, J.; Nduati, R.; Mbori-Ngacha, D.; Rostron, T.; Dong, T.; Kostrikis, Leontios G.; Richardson, B.; Rowland-Jones, S. L. (2001)

The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Δ32 mutation, which is associated with resistance to ...

Article

Cellular HIV type 1 DNA levels are equivalent among drug-sensitive and drug-resistant strains in newly diagnosed and antiretroviral naive patients

Antoniadou, Zoi Anna; Hezka, Johana; Kousiappa, Ioanna; Mamais, Ioannis A.; Skoura, Lemonia G.; Pilalas, Dimitrios; Metallidis, Simeon A.; Nicolaidis, Pavlos; Malisiovas, Nikolaos; Kostrikis, Leontios G. (2014)

The emergence of resistance against current antiretroviral drugs to human immunodeficiency virus type 1 (HIV-1) is an increasingly important concern to the continuous success of antiretroviral therapy to HIV-1-infected ...

Article

Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe

Demetriou, Victoria L.; van de Vijver, D. A. M. C.; Kousiappa, Ioanna; Balotta, Claudia; Clotet, B.; Grossman, Z.; Jørgensen, L. B.; Lepej, S. Z.; Levy, I.; Nielsen, C.; Paraskevis, Dimitrios N.; Poljak, M.; Roman, F.; Ruiz, L.; Schmidt, J. -C; Vandamme, A. -M; van Laethem, K. V.; Vercauteren, J.; Kostrikis, Leontios G. (2010)

Background HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe. Studies have demonstrated that HIV-1 DNA load in ...

Article

Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy

Hatzakis, Angelos E.; Touloumi, G.; Pantazis, N.; Anastassopoulou, C. G.; Katsarou, O.; Karafoulidou, A.; Goedert, J. J.; Kostrikis, Leontios G. (2004)

Objective: To assess whether cellular HIV-1 DNA prior to highly active antiretroviral therapy (HAART) initiation predicts its outcome. Design and methods: Patients included all 51 hemophiliacs of the Greek component of the ...

Article

Changes in T Cell Receptor Excision DNA Circle (TREC) Levels in HIV Type 1-Infected Subjects Pre- and Post-Highly Active Antiretroviral Therapy

Touloumi, G.; Pantazis, N.; Karafoulidou, A.; Mandalaki, T.; Goedert, J. J.; Kostrikis, Leontios G.; Hatzakis, Angelos E. (2004)

The T cell receptor excision DNA circle (TREC) level is an independent predictor of HIV-1 disease prognosis. We studied the temporal changes in TREC levels prior to and after highly active antiretroviral therapy (HAART) ...

Article

Click evoked neurogenic vestibular potentials (NVESTEPs): A method of assessing the function of the vestibular system

Papathanasiou, Eleftherios Stelios; Zamba-Papanicolaou, Eleni; Pantzaris, Marios C.; Kyriakides, Theodoros; Papacostas, Savvas S.; Myrianthopoulou, Panayiota; Pattichis, Constantinos S.; Iliopoulos, Ioannis Komotini; Piperidou, Charitomeni N. (2003)

Objectives: To obtain neurogenic vestibular evoked potentials (NVESTEPs) with surface scalp recording using high intensity auditory clicks. The same stimulus is used in myogenic vestibular evoked potentials which has been ...

Article

Clinical aspects of cystinuria

Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (1997)

Article

COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy

Voskarides, Konstantinos; Damianou, Loukas; Neocleous, Vassos; Zouvani, Ioanna; Christodoulidou, Stalo; Hadjiconstantinou, Valsamakis E.; Ioannou, Kyriakos; Athanasiou, Yiannis; Patsias, Charalambos; Alexopoulos, Efstathios; Pierides, Alkis M.; Kyriacou, Kyriacos C.; Constantinou-Deltas, Constantinos D. (2007)

Mutations in the COL4A3/COL4A4 genes of type IV collagen have been found in ∼40% of cases of thin basement membrane nephropathy, which is characterized by microscopic hematuria and is classically thought to cause proteinuria ...

Article

Comparative developmental anatomy of the murine and human definitive placentae

Georgiades, Pantelis; Fergyson-Smith, A. C.; Burton, G. J. (2002)

The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary ...

Article

Comparison of Two Different Doses of Ondansetron plus Dexamethasone in the Prophylaxis of Cisplatin-lnduced Emesis

Pectasides, Dimitrios; Mylonakis, Alexander; Varthalitis, John; Kostopoulou, Mary; Constantinou, Andreas I.; Papazachariou, Kathrin; Antoniou, Fotini; Dimitriadis, Michael; Athanassiou, Athanassios E. (1997)

This study was conducted to evaluate the efficacy of two different doses of ondansetron (8 mg vs. 24 mg) plus dexamethasone in the prevention of cisplatin (CDDP)-induced emesis and nausea (acute and delayed). The persistence ...

Article

A Comparison of Ultrasound Intima-Media Thickness Measurements of the Left and Right Common Carotid Artery

Loizou, Christos P.; Nicolaïdes, Andrew N.; Kyriacou, Efthyvoulos C.; Georghiou, N.; Griffin, Maura B.; Pattichis, Constantinos S. (2015)

The intima-media thickness (IMT) of the common carotid artery (CCA) is an established indicator of cardiovascular disease (CVD). There have been reports about the difference between the left and the right sides of the CCA ...

Article

Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met

Dardiotis, Efthymios; Koutsou, Pantelitsa; Zamba-Papanicolaou, Eleni; Vonta, Filia; Hadjivassiliou, Marilena; Hadjigeorgiou, Georgios M.; Cariolou, Marios A.; Christodoulou, Kyproula; Kyriakides, Theodoros (2009)

Background: Familial amyloidotic polyneuropathy (FAP) TTR Val30Met is a lethal autosomal dominant sensorimotor and autonomic neuropathy due to a substitution of methionine for valine at position 30 of the transthyretin ...