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Browsing by Subject "bacterial virulence"

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    • Article  

      Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity 

      Apidianakis, Yiorgos; Christofi, T. (2013)
      Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...

    • Article  

      Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection 

      Apidianakis, Yiorgos; Rahme, L. G. (2009)
      Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...

    • Article  

      Drosophila melanogaster: A first step and a stepping-stone to anti-infectives 

      Tzelepis, Ilias; Kapsetaki, Stefania Elisavet; Panayidou, S.; Apidianakis, Yiorgos (2013)
      Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...

    • Article  

      Homeostatic interplay between bacterial cell-cell signaling and iron in virulence 

      Hazan, R.; He, J.; Xiao, G.; Dekimpe, V.; Apidianakis, Yiorgos; Lesic, B.; Astrakas, C.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2010)
      Pathogenic bacteria use interconnected multi-layered regulatory networks, such as quorum sensing (QS) networks to sense and respond to environmental cues and external and internal bacterial cell signals, and thereby adapt ...

    • Article  

      Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Tegos, G. P.; Papisov, M. I.; Hamblin, M. R.; Davis, R. W.; Tompkins, R. G.; Rahme, L. G. (2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

    • Article  

      Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer 

      Markou, P.; Apidianakis, Yiorgos (2014)

    • Article  

      The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria 

      An, D.; Apidianakis, Yiorgos; Boechat, A. L.; Baldini, R. L.; Goumnerov, B. C.; Rahme, L. G. (2009)
      Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments ...

    • Article  

      Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Lau, G. W.; Baldini, R. L.; Davis, R. W.; Rahme, L. G. (2005)
      Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...

    • Article  

      A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes 

      Kesarwani, M.; Hazan, R.; He, J.; Que, Y.; Apidianakis, Yiorgos; Lesic, B.; Xiao, G.; Dekimpe, V.; Milot, S.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2011)
      A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...

    • Article  

      Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites 

      Christofi, T.; Apidianakis, Yiorgos (2013)
      The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, ...

    • Article  

      Use of molecular beacons and multi-allelic real-time PCR for detection of and discrimination between virulent Bacillus anthracis and other Bacillus isolates 

      Hadjinicolaou, Andreas V.; Demetriou, Victoria L.; Hezka, Johana; Beyer, W.; Hadfield, T. L.; Kostrikis, Leontios G. (2009)
      The awareness of the threat of Bacillus anthracis, the causative agent of the disease anthrax, as a biowarfare and bioterrorism weapon has revived the development of new technologies for rapid and accurate detection of ...

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