Browsing by Subject "catalysis"

Article

Catalytic activity of high surface area mesoporous mn-based mixed oxides for the deep oxidation of methane and lean-nox reduction

Stathopoulos, Vassilis N.; Belessi, Vassiliki C.; Costa, Costas N.; Neophytides, Stylianos G.; Falaras, Polycarpos; Efstathiou, Angelos M.; Pomonis, Phillippos J. (2000)

Article

Characterization and magnetic properties of a "super stable" radical 1,3-diphenyl-7-trifluoromethyl-1,4-dihydro-1,2,4-benzotriazin-4-yl

Constantinides, Christos P.; Koutentis, Panayiotis Andreas; Krassos, H.; Rawson, J. M.; Tasiopoulos, Anastasios J. (2011)

1,3-Diphenyl-7-trifluoromethyl-1,4-dihydro-1,2,4-benzotriazin-4-yl (4), prepared in SSSShigh yield via the catalytic oxidation of the corresponding amidrazone 5 by using Pd/C (1.6 mol ss%) and 1,8-diazabicyclo[5.4.0]undec-7-ene ...

Article

The Conversion of 4-Anilinoquinazoline- and 3-Aryl-4-imino-3,4-dihydro-quinazoline-2-carbonitriles into Benzo[4,5]imidazo[1,2-c]quinazoline-6-carbonitriles via Oxidative and Nonoxidative C-N Couplings

Mirallai, Styliana I.; Koutentis, Panayiotis Andreas (2015)

Benzo[4,5]imidazo[1,2-c]quinazoline-6-carbonitriles are prepared in high yields via three new routes: (1) a Cu(OTf)2 (0-5 mol %) catalyzed hypervalent iodine [PhI(OTf)2] mediated oxidative coupling of 4-anilinoquinazolin ...

Article

Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection

Apidianakis, Yiorgos; Que, Y. -A; Xu, W.; Tegos, G. P.; Zimniak, P.; Hamblin, M. R.; Tompkins, R. G.; Xiao, W.; Rahme, L. G. (2012)

Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...

Article

Formation of oligotriazoles catalysed by cucurbituril

Krasia-Christoforou, T.; Steinke, J. H. G. (2002)

The catalytic activity of cucurbituril in 1,3-dipolar cycloadditions has been applied to the synthesis of oligotriazoles.

Article

Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues

Archontis, Georgios Z.; Watson, K. A.; Xie, Q.; Andreou, Georgia; Chrysina, Evangelia D.; Zographos, Spyros E.; Oikonomakos, Nikos G.; Karplus, M. (2005)

GP catalyzes the phosphorylation of glycogen to Glc-1-P. Because of its fundamental role in the metabolism of glycogen, GP has been the target for a systematic structure-assisted design of inhibitory compounds, which could ...

Article

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Watson, K. A.; Chrysina, Evangelia D.; Tsitsanou, K. E.; Zographos, Spyros E.; Archontis, Georgios Z.; Fleet, G. W. J.; Oikonomakos, Nikos G. (2005)

Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-β-D-glucopyranosylamine have been identified ...

Article

Microwave assisted synthesis of 3-aminoindole-2-carbonitriles from anthranilonitriles via N-unprotected 2-(cyanomethylamino)benzonitriles

Michaelidou, Sophia S.; Koutentis, Panayiotis Andreas (2010)

Anthranilonitrile 3a, 4,5-dimethoxyanthranilonitrile 3b and 5-nitroanthranilonitrile 3c, react with paraformaldehyde, KCN and ZnCl2 in acetic acid under acid catalysis (H2SO4) in a sealed tube at ca. 55 °C to give the ...

Article

Monolayer properties of surface-active metalorganic complexes with a tunable headgroup

Mallouri, R.; Keramidas, Anastasios D.; Brezesinski, G.; Leontidis, Epameinondas (2008)

Surface-active metalorganic complexes can be used to construct organic thin films with excellent electronic and catalytic properties. We have recently introduced a new versatile surface-active ligand, which can efficiently ...

Article

The origin of the Fe IV = O intermediates in cytochrome aa 3 oxidase

Pinakoulaki, Eftychia; Daskalakis, Vangelis; Varotsis, Constantinos (2012)

The dioxygen reduction mechanism in cytochrome oxidases relies on proton control of the electron transfer events that drive the process. Proton delivery and proton channels in the protein that are relevant to substrate ...

Article

Palladium catalyzed C-C coupling reactions of 3,5-dichloro-4 H -1,2,6-thiadiazin-4-one

Ioannidou, Heraklidia A.; Kizas, Christos M.; Koutentis, Panayiotis Andreas (2011)

Palladium catalyzed Suzuki-Miyaura, Stille, and Sonogashira coupling reactions are reported for the electron-deficient heterocyclic scaffold 3,5-dichloro-4H-1,2,6-thiadiazin-4-one (1). Furthermore, 3,5-di(thien-2-yl)-4H- ...

Article

Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex

Constantinou, Andreas I.; Husband, A. (2002)

Cancer therapeutic drugs that inhibit DNA topoisomerase (topo) II by stabilizing the cleavable complex are collectively known as topo II poisons. Phenoxodiol is a synthetic derivative of the plant isoflavone daidzein and ...

Article

Reactivation of an aged commercial three-way catalyst by oxalic and citric acid washing

Christou, Stavroula Y.; Birgersson, H.; Fierro, José Luis García; Efstathiou, Angelos M. (2006)

The efficiency of dilute oxalic and citric acid solutions on improving the oxygen storage capacity (OSC) and catalytic activity of a severely aged (83 000 km) commercial three-way catalyst (TWC) has been investigated. ...

Article

Recognition of ribonuclease A by 3′-5′-pyrophosphate-linked dinucleotide inhibitors: A molecular dynamics/continuum electrostatics analysis

Polydoridis, Savvas; Leonidas, Demetres D.; Oikonomakos, Nikos G.; Archontis, Georgios Z. (2007)

The proteins of the pancreatic ribonuclease A (RNase A) family catalyze the cleavage of the RNA polymer chain. The development of RNase inhibitors is of significant interest, as some of these compounds may have a therapeutic ...

Article

Reinvestigating the synthesis of N-arylbenzamidines from benzonitriles and anilines in the presence of AlCl3

Koutentis, Panayiotis Andreas; Mirallai, Styliana I. (2010)

The preparation of N-phenylbenzamidine 3a from the reaction between benzonitrile Ia and aniline in the presence of AId3 is reinvestigated with respect to mode of reagent addition, reaction temperature and Lewis acid ...

Article

The remarkable effect of oxygen on the N2 selectivity of water catalytic denitrification by hydrogen

Constantinou, C. L.; Costa, Costas N.; Efstathiou, Angelos M. (2007)

The selective catalytic reduction of nitrates (NO3-) in pure water toward N2 formation by the use of gaseous H2 and in the presence of O2 (air) at 1 atm total pressure and 25°C has been investigated over Pd-Cu supported ...

Article

The role of the cross-link His-Tyr in the functional properties of the binuclear center in cytochrome c oxidase

Pinakoulaki, Eftychia; Pfitzner, U.; Ludwig, B.; Varotsis, Constantinos (2002)

Resonance Raman and Fourier transform infrared spectroscopies have been used to study the aa3-type cytochrome c oxidase and the Y280H mutant from Paracoccus denitrificans. The stability of the binuclear center in the absence ...

Article

Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity

Cho, K. H.; Pezzuto, J. M.; Bolton, J. L.; Steele, V. E.; Kelloff, G. J.; Lee, S. K.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...

Article

Silver-mediated palladium-catalyzed direct C-H arylation of 3-bromoisothiazole-4-carbonitrile

Ioannidou, Heraklidia A.; Koutentis, Panayiotis Andreas (2011)

Silver(I) fluoride-mediated Pd-catalyzed C-H direct arylation/ heteroarylation of 3-bromoisothiazole-4-carbonitrile (1a) gives twenty-four 5-aryl/heteroaryl-3-bromoisothiazole-4-carbonitriles. The reaction was partially ...

Article

Simultaneous resonance Raman detection of the heme a3-Fe-CO and CuB-CO species in CO-bound ba3-cytochrome c oxidase from Thermus thermophilus: Evidence for a charge transfer CuB-CO transition

Pinakoulaki, Eftychia; Ohta, T.; Soulimane, T.; Kitagawa, T.; Varotsis, Constantinos (2004)

Understanding of the chemical nature of the dioxygen and nitric oxide moiety of ba3-cytochrome c oxidase from Thermus thermophilus is crucial for elucidation of its physiological function. In the present work, direct ...