Browsing by Subject "drug derivative"

Article

Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells

Muro, E.; Fragola, A.; Pons, T.; Lequeux, N.; Ioannou, Androulla; Skourides, Paris A.; Dubertret, B. (2012)

The in vivo labeling of intracellular components with quantum dots (QDs) is very limited because of QD aggregation in the cell cytoplasm and/or QD confinement into lysosomal compartments. In order to improve intracellular ...

Article

Computational protein design: The proteus software and selected applications

Simonson, T.; Gaillard, T.; Mignon, D.; Schmidt Am Busch, M.; Lopes, A.; Amara, Najette; Polydorides, Savvas; Sedano, A.; Druart, Karen; Archontis, Georgios Z. (2013)

We describe an automated procedure for protein design, implemented in a flexible software package, called Proteus. System setup and calculation of an energy matrix are done with the XPLOR modeling program and its sophisticated ...

Article

Detection of the His-heme Fe2+-NO species in the reduction of NO to N2O by ba3-oxidase from thermus thermophilus

Pinakoulaki, Eftychia; Ohta, T.; Soulimane, T.; Kitagawa, T.; Varotsis, Constantinos (2005)

Reaction pathways in the enzymatic formation and cleavage of the N-N and N-O bonds, respectively, are difficult to verify without the structure of the intermediates, but we now have such information on the heme a3 2+-NO ...

Article

Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro

Pisha, E.; Lui, X.; Constantinou, Andreas I.; Bolton, J. L. (2001)

Estrogen replacement therapy has been correlated with an increased risk of developing hormone-dependent cancers. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin and equilin which are components of the ...

Article

Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives.

Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)

Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...

Article

MRI-based morphological modeling, synthesis and characterization of cardiac tissue-mimicking materials

Kossivas, Fotis; Angeli, Stelios I.; Kafouris, Demetris; Patrickios, Costas S.; Tzagarakis, V.; Constantinides, Christakis (2012)

This study uses standard synthetic methodologies to produce tissue-mimicking materials that match the morphology and emulate the in vivo murine and human cardiac mechanical and imaging characteristics, with dynamic mechanical ...

Article

Nickel/lanthanide single-molecule magnets: {Ni3Ln} "stars" with a ligand derived from the metal-promoted reduction of di-2-pyridyl ketone under solvothermal conditions

Efthymiou, Constantinos G.; Stamatatos, Theocharis C.; Papatriantafyllopoulou, Constantina; Tasiopoulos, Anastasios J.; Wernsdorfer, W.; Perlepes, Spyros P.; Christou, George (2010)

Unusual {NiII3LnIII(μ-OR) 6}3+ complexes with a "star" topology have been prepared with ligands derived from the metal-promoted reduction of di-2-pyridyl ketone under solvothermal conditions

Article

The phosphoform of the regulatory subunit RII of cyclic AMP-dependent protein kinase possesses intrinsic topoisomerase activity

Constantinou, Andreas I.; Squinto, S. P.; Jungmann, R. A. (1985)

The phosphoform of the type II regulatory subunit (phospho-RII-cAMP) of cAMP-dependent protein kinase from rat liver was found to possess intrinsic topoisomerase activity towards several DNA substrates such as φX174, pBR322, ...

Article

Preparation of a psammaplysene-based library

Georgiades, Savvas N.; Clardy, J. (2006)

(Chemical Equation Presented) A 28-member focused library, based on the pseudosymmetric template of the marine alkaloids psammaplysenes, was prepared from combinations of components that were, in turn, derived from ...

Article

Qualitative and quantitative determination of COPs in cypriot meat samples using HPLC determination of the most effective sample preparation procedure

Georgiou, Christiana A.; Kapnissi‐Christodoulou, Constantina P. (2013)

This research work describes the development of a fast high-performance liquid chromatography method for the simultaneous determination of five important cholesterol oxidation products (COPs). The influence of various ...

Article

Separation of acetylcholinesterase inhibitors using polymeric surfactants in polyelectrolyte multilayer coatings

Constantinou, A. S.; Nicolaou, I. N.; Kapnissi‐Christodoulou, Constantina P. (2012)

The main objective of this study is the use of polymeric surfactants in polyelectrolyte multilayer (PEM) coatings for the separation of the pharmaceutical substances acetylcholinesterase inhibitors (AChEIs). AChEIs are ...

Article

Synthesis and structural characterization of new cu(I) complexes with the antithyroid drug 6-n-propyl-thiouracil. Study of the cu(I)-catalyzed intermolecular cycloaddition of iodonium ylides toward benzo[b]furans with pharmaceutical implementations

Paizanos, K.; Charalampou, D. C.; Kourkoumelis, Nikolaos; Kalpogiannaki, Dimitra; Hadjiarapoglou, Lazaros P.; Spanopoulou, A.; Lazarou, Konstantinos; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Kubicki, Maciej; Hadjikakou, Sotiris K. (2012)

The reaction of copper(I) iodide with 6-n-propylthiouracil (ptu) in the presence or absence of the triphenylphosphine (tpp) or tri(p-tolyl)phosphine (tptp) in a 1:1:2 molar ratio forms the mixed ligand Cu(I) complex with ...

Article

Targeting colon cancer cells with genistein-17.1A immunoconjugate.

Gentile, M. S.; Vasu, C.; Green, A.; Murillo, G.; Das Gupta, T. K.; Constantinou, Andreas I.; Prabhakar, B. S.; Salti, G. I. (2003)

We have shown that genistein, a major component of soy, has anti-colon cancer effects in vitro. These effects are attainable at high concentrations that are difficult to achieve in the serum. The purpose of this study was ...

Article

Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes.

Stylianopoulos, T.; Kokonou, M.; Michael, S.; Tryfonos, A.; Rebholz, Claus; Odysseos, A. D.; Doumanidis, C. C. (2012)

The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...

Article

Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export

Georgiades, Savvas N.; Clardy, J. (2005)

(Chemical Equation Presented) Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare ...

Article

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

Constantinou, Constantina; Papas, Andreas M.; Constantinou, Andreas I. (2008)

Current observations in the literature suggest that vitamin E may be a suitable candidate for the adjuvant treatment of cancer. Even though historically most research focused on α-tocopherol, more recent evidence suggests ...