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Browsing by Subject "drug derivative"

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    • Article  

      Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells 

      Muro, E.; Fragola, A.; Pons, T.; Lequeux, N.; Ioannou, Androulla; Skourides, Paris A.; Dubertret, B. (2012)
      The in vivo labeling of intracellular components with quantum dots (QDs) is very limited because of QD aggregation in the cell cytoplasm and/or QD confinement into lysosomal compartments. In order to improve intracellular ...

    • Article  

      Computational protein design: The proteus software and selected applications 

      Simonson, T.; Gaillard, T.; Mignon, D.; Schmidt Am Busch, M.; Lopes, A.; Amara, Najette; Polydorides, Savvas; Sedano, A.; Druart, Karen; Archontis, Georgios Z. (2013)
      We describe an automated procedure for protein design, implemented in a flexible software package, called Proteus. System setup and calculation of an energy matrix are done with the XPLOR modeling program and its sophisticated ...

    • Article  

      Detection of the His-heme Fe2+-NO species in the reduction of NO to N2O by ba3-oxidase from thermus thermophilus 

      Pinakoulaki, Eftychia; Ohta, T.; Soulimane, T.; Kitagawa, T.; Varotsis, Constantinos (2005)
      Reaction pathways in the enzymatic formation and cleavage of the N-N and N-O bonds, respectively, are difficult to verify without the structure of the intermediates, but we now have such information on the heme a3 2+-NO ...

    • Article  

      Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro 

      Pisha, E.; Lui, X.; Constantinou, Andreas I.; Bolton, J. L. (2001)
      Estrogen replacement therapy has been correlated with an increased risk of developing hormone-dependent cancers. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin and equilin which are components of the ...

    • Article  

      Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives. 

      Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)
      Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...

    • Article  

      MRI-based morphological modeling, synthesis and characterization of cardiac tissue-mimicking materials 

      Kossivas, Fotis; Angeli, Stelios I.; Kafouris, Demetris; Patrickios, Costas S.; Tzagarakis, V.; Constantinides, Christakis (2012)
      This study uses standard synthetic methodologies to produce tissue-mimicking materials that match the morphology and emulate the in vivo murine and human cardiac mechanical and imaging characteristics, with dynamic mechanical ...

    • Article  

      Nickel/lanthanide single-molecule magnets: {Ni3Ln} "stars" with a ligand derived from the metal-promoted reduction of di-2-pyridyl ketone under solvothermal conditions 

      Efthymiou, Constantinos G.; Stamatatos, Theocharis C.; Papatriantafyllopoulou, Constantina; Tasiopoulos, Anastasios J.; Wernsdorfer, W.; Perlepes, Spyros P.; Christou, George (2010)
      Unusual {NiII3LnIII(μ-OR) 6}3+ complexes with a "star" topology have been prepared with ligands derived from the metal-promoted reduction of di-2-pyridyl ketone under solvothermal conditions

    • Article  

      The phosphoform of the regulatory subunit RII of cyclic AMP-dependent protein kinase possesses intrinsic topoisomerase activity 

      Constantinou, Andreas I.; Squinto, S. P.; Jungmann, R. A. (1985)
      The phosphoform of the type II regulatory subunit (phospho-RII-cAMP) of cAMP-dependent protein kinase from rat liver was found to possess intrinsic topoisomerase activity towards several DNA substrates such as φX174, pBR322, ...

    • Article  

      Preparation of a psammaplysene-based library 

      Georgiades, Savvas N.; Clardy, J. (2006)
      (Chemical Equation Presented) A 28-member focused library, based on the pseudosymmetric template of the marine alkaloids psammaplysenes, was prepared from combinations of components that were, in turn, derived from ...

    • Article  

      Qualitative and quantitative determination of COPs in cypriot meat samples using HPLC determination of the most effective sample preparation procedure 

      Georgiou, Christiana A.; Kapnissi‐Christodoulou, Constantina P. (2013)
      This research work describes the development of a fast high-performance liquid chromatography method for the simultaneous determination of five important cholesterol oxidation products (COPs). The influence of various ...

    • Article  

      Separation of acetylcholinesterase inhibitors using polymeric surfactants in polyelectrolyte multilayer coatings 

      Constantinou, A. S.; Nicolaou, I. N.; Kapnissi‐Christodoulou, Constantina P. (2012)
      The main objective of this study is the use of polymeric surfactants in polyelectrolyte multilayer (PEM) coatings for the separation of the pharmaceutical substances acetylcholinesterase inhibitors (AChEIs). AChEIs are ...

    • Article  

      Synthesis and structural characterization of new cu(I) complexes with the antithyroid drug 6-n-propyl-thiouracil. Study of the cu(I)-catalyzed intermolecular cycloaddition of iodonium ylides toward benzo[b]furans with pharmaceutical implementations 

      Paizanos, K.; Charalampou, D. C.; Kourkoumelis, Nikolaos; Kalpogiannaki, Dimitra; Hadjiarapoglou, Lazaros P.; Spanopoulou, A.; Lazarou, Konstantinos; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Kubicki, Maciej; Hadjikakou, Sotiris K. (2012)
      The reaction of copper(I) iodide with 6-n-propylthiouracil (ptu) in the presence or absence of the triphenylphosphine (tpp) or tri(p-tolyl)phosphine (tptp) in a 1:1:2 molar ratio forms the mixed ligand Cu(I) complex with ...

    • Article  

      Targeting colon cancer cells with genistein-17.1A immunoconjugate. 

      Gentile, M. S.; Vasu, C.; Green, A.; Murillo, G.; Das Gupta, T. K.; Constantinou, Andreas I.; Prabhakar, B. S.; Salti, G. I. (2003)
      We have shown that genistein, a major component of soy, has anti-colon cancer effects in vitro. These effects are attainable at high concentrations that are difficult to achieve in the serum. The purpose of this study was ...

    • Article  

      Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes. 

      Stylianopoulos, T.; Kokonou, M.; Michael, S.; Tryfonos, A.; Rebholz, Claus; Odysseos, A. D.; Doumanidis, C. C. (2012)
      The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...

    • Article  

      Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export 

      Georgiades, Savvas N.; Clardy, J. (2005)
      (Chemical Equation Presented) Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare ...

    • Article  

      Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs 

      Constantinou, Constantina; Papas, Andreas M.; Constantinou, Andreas I. (2008)
      Current observations in the literature suggest that vitamin E may be a suitable candidate for the adjuvant treatment of cancer. Even though historically most research focused on α-tocopherol, more recent evidence suggests ...

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