Browsing by Subject "histone"

Article

Beyond the histone tail: acetylation at the nucleosome dyad commands transcription.

Molina-Serrano, D.; Kirmizis, Antonis (2013)

Post-translational modifications (PTMs) of histones have been implicated in cellular processes such as transcription, replication and DNA repair. These processes normally involve dynamic changes in chromatin structure and ...

Article

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

Kuzmichev, A.; Margueron, R.; Vaquero, A.; Preissner, T. S.; Scher, M.; Kirmizis, Antonis; Ouyang, X.; Brockdorff, N.; Abate-Shen, C.; Farnham, P.; Reinberg, D. (2005)

Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to have a profound effect on gene expression through epigenetics. Ezh2 is a histone-lysine ...

Article

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway

Pavlou, Demos; Kirmizis, Antonis (2016)

Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...

Article

Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity

Molina-Serrano, D.; Schiza, V.; Demosthenous, Christis; Stavrou, Emmanouil; Oppelt, J.; Kyriakou, DImitris; Liu, W.; Zisser, G.; Bergler, H.; Dang, W.; Kirmizis, Antonis (2016)

Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...

Article

Steps toward understanding the inheritance of repressive methyl-lysine marks in histones

Reinberg, D.; Chuikov, S.; Farnham, P.; Karachentsev, D.; Kirmizis, Antonis; Kuzmichev, A.; Margueron, R.; Nishioka, K.; Preissner, T. S.; Sarma, K.; Abate-Shen, C.; Steward, R.; Vaquero, A. (2004)

Article

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

Marion, R. M.; Strati, K.; Li, H.; Tejera, A.; Schoeftner, S.; Ortega, S.; Serrano, M.; Blasco, M. A. (2009)

Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients