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Browsing by Subject "immune response"

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    • Article  

      Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity 

      Apidianakis, Yiorgos; Christofi, T. (2013)
      Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...

    • Article  

      Drosophila melanogaster as a model for human intestinal infection and pathology 

      Apidianakis, Yiorgos; Rahme, L. G. (2011)
      Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...

    • Article  

      Drosophila melanogaster: A first step and a stepping-stone to anti-infectives 

      Tzelepis, Ilias; Kapsetaki, Stefania Elisavet; Panayidou, S.; Apidianakis, Yiorgos (2013)
      Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...

    • Article  

      Effects of in Vivo CD8+ T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine 

      Metzner, K. J.; Jin, X.; Lee, F. V.; Gettie, A.; Bauer, D. E.; Di Mascio, M.; Perelson, A. S.; Marx, P. A.; Ho, David D.; Kostrikis, Leontios G.; Connor, R. I. (2000)
      The role of CD8+ T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque ...

    • Article  

      HIV-1 vaccine strategies utilizing viral vectors including antigen-displayed inoviral vectors 

      Hassapis, K. A.; Kostrikis, Leontios G. (2013)
      Antigen-presenting viral vectors have been extensively used as vehicles for the presentation of antigens to the immune system in numerous vaccine strategies. Particularly in HIV vaccine development efforts, two main viral ...

    • Article  

      HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 Δ32-negative female sex workers in Chiang Rai, northern Thailand 

      Sriwanthana, B.; Hodge, T.; Mastro, T. D.; Dezzutti, C. S.; Bond, K.; Stephens, H. A. F.; Kostrikis, Leontios G.; Limpakarnjanarat, K.; Young, N. L.; Qari, S. H.; Lal, R. B.; Chandanayingyong, D.; McNicholl, J. M. (2001)
      Understanding how highly HIV-exposed individuals remain HIV uninfected may be useful for HIV vaccine design and development of new HIV prevention strategies. To elucidate mechanisms associated with resistance to HIV ...

    • Article  

      Human pathogenic bacteria, fungi, and viruses in Drosophila 

      Panayidou, S.; Ioannidou, E.; Apidianakis, Yiorgos (2014)
      Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...

    • Article  

      Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells 

      Bangi, E.; Pitsouli, Chrysoula; Rahme, L. G.; Cagan, R.; Apidianakis, Yiorgos (2012)
      Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...

    • Article  

      Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Tegos, G. P.; Papisov, M. I.; Hamblin, M. R.; Davis, R. W.; Tompkins, R. G.; Rahme, L. G. (2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

    • Article  

      Modeling hologenome imbalances in inflammation and cancer 

      Apidianakis, Yiorgos; Ferrandon, D. (2014)

    • Article  

      Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Lau, G. W.; Baldini, R. L.; Davis, R. W.; Rahme, L. G. (2005)
      Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...

    • Article  

      Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites 

      Christofi, T.; Apidianakis, Yiorgos (2013)
      The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, ...

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