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Browsing by Subject "mesoderm"

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    • Article  

      Calpain2 protease: A new member of the Wnt/Ca2+ pathway modulating convergent extension movements in Xenopus 

      Zanardelli, Sara; Christodoulou, Neophytos; Skourides, Paris A. (2013)
      Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate several physiological processes by limited cleavage of different substrates. The role of Calpain2 in embryogenesis is not clear with ...

    • Article  

      A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)
      FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...

    • Article  

      Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development 

      Georgiades, Pantelis; Rossant, J. (2006)
      Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted ...

    • Article  

      Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation 

      Polydorou, Christiana; Georgiades, Pantelis (2013)
      Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive ...

    • Article  

      Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals 

      Stylianou, Panayiota; Skourides, Paris A. (2009)
      Mesoderm migration is a well studied morphogenetic movement that takes place during Xenopus gastrulation. The study of mesoderm migration and other morphogenetic movements has been primarily based on in vitro assays due ...

    • Article  

      The mouse Foxi3 transcription factor is necessary for the development of posterior placodes 

      Birol, O.; Ohyama, T.; Edlund, R. K.; Drakou, Katerina; Georgiades, Pantelis; Groves, A. K. (2016)
      The inner ear develops from the otic placode, one of the cranial placodes that arise from a region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We have identified a Forkhead family ...

    • Article  

      Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12 

      Georgiades, Pantelis; Watkins, M.; Surani, M. A.; Ferguson-Smith, A. C. (2000)
      Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted

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