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Browsing by Subject "pathophysiology"

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    • Article  

      Autosomal dominant tubulointerstitial kidney disease: Diagnosis, classification, and management - A KDIGO consensus report 

      Eckardt, K. -U; Alper, S. L.; Antignac, C.; Bleyer, A. J.; Chauveau, D.; Dahan, K.; Constantinou-Deltas, Constantinos D.; Hosking, A.; Kmoch, S.; Rampoldi, L.; Wiesener, M.; Wolf, M. T.; Devuyst, O. (2015)
      Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been ...

    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...

    • Article  

      Evolution of osmotic pressure in solid tumors 

      Voutouri, C.; Stylianopoulos, T. (2014)
      The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...

    • Article  

      Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Tegos, G. P.; Papisov, M. I.; Hamblin, M. R.; Davis, R. W.; Tompkins, R. G.; Rahme, L. G. (2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

    • Article  

      Low frequency of CCR5Δ32 allele among Greeks in Cyprus 

      Christodoulou, Chris C.; Poullikas, M.; Neumann, A. U.; Kostrikis, Leontios G. (1997)

    • Article  

      Manual and automated intima-media thickness and diameter measurements of the common carotid artery in patients with renal failure disease 

      Loizou, Christos P.; Kasparis, Takis; Lazarou, Theodoros; Pattichis, Constantinos S.; Pantzaris, Marios C. (2014)
      The objective of this study was to investigate differences in intima-media thickness (IMT) and diameter (D) measurements of the common carotid artery (CCA) in ultrasound imaging in normal subjects and renal failure disease ...

    • Article  

      Multiscale entropy-based approach to automated surface EMG classification of neuromuscular disorders 

      Istenič, R.; Kaplanis, P. A.; Pattichis, Constantinos S.; Zazula, D. (2010)
      We introduce a novel method for an automatic classification of subjects to those with or without neuromuscular disorders. This method is based on multiscale entropy of recorded surface electromyograms (sEMGs) and support ...

    • Article  

      Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors 

      Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)
      Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...

    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...

    • Article  

      Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

    • Article  

      A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth 

      Vavourakis, V.; Wijeratne, P. A.; Shipley, R.; Loizidou, M.; Stylianopoulos, T.; Hawkes, D. J. (2017)
      Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...

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