Browsing by Subject "virus enzyme"
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Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions (2002)We report the emergence of drug-resistant viral mutations in chronically HIV-infected individuals undergoing structured treatment interruptions (STI). The protease mutation M46L and the reverse transcriptase mutations K101E ...
Identification of a series of novel derivatives as potent HCV inhibitors by a ligand-based virtual screening optimized procedure (2007)This paper presents the results of a ligand-based virtual screening optimized procedure on 98 compounds which have been recently evaluated as inhibitors of genotype 1 HCV polymerase. First, quantitative structure-activity ...