Browsing by Author "Murphy,Declan G. M."
Now showing items 1-19 of 19
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Biological sex affects the neurobiology of autism
Lai,Meng-Chuan; Lombardo,Michael V.; Suckling,John; Ruigrok,Amber N. V.; Chakrabarti,B.; Ecker,C.; Deoni,Sean C. L.; Craig, Michael C.; Murphy,Declan G. M.; Bullmore,Edward T.; Baron-Cohen,Simon (2013)In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females ...
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Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: A multicenter magnetic resonance imaging study
Ecker,C.; Suckling,John; Deoni,Sean C. L.; Lombardo,Michael V.; Bullmore,Edward T.; Baron-Cohen,Simon; Catani, Marco; Jezzard, Peter; Barnes, Anna; Bailey, Anthony J.; Williams,Steven C. R.; Murphy,Declan G. M. (2012)Context: There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well as how these relate to behavioral variation, ...
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Brain surface anatomy in adults with autism: The relationship between surface area, cortical thickness, and autistic symptoms
Ecker,C.; Ginestet, Cedric E.; Feng, Yue; Johnston,Patrick; Lombardo,Michael V.; Lai,Meng-Chuan; Suckling,John; Palaniyappan, Lena; Daly,Eileen M.; Murphy,Clodagh M.; Williams,Steven C. R.; Bullmore,Edward T.; Baron-Cohen,Simon; Brammer, Michael; Murphy,Declan G. M. (2013)Context: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and ...
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Cognition in Males and Females with Autism: Similarities and Differences
Lai,Meng-Chuan; Lombardo,Michael V.; Ruigrok,Amber N. V.; Chakrabarti,B.; Wheelwright,Sally J.; Auyeung, Bonnie; Allison, Carrie; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Williams,Steven C. R.; Baron-Cohen,Simon (2012)The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ...
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The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...
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Frontal networks in adults with autism spectrum disorder
Catani, Marco; Dell’Acqua, Flavio; Budisavljevic, Sanja; Howells, Henrietta; Schotten, Thiebaut De; Froudist-Walsh, Sean; D'Anna, Lucio; Thompson, A.; Sandrone, Stefano; Bullmore,Edward T.; Suckling,John; Baron-Cohen,Simon; Lombardo,Michael V.; Wheelwright,Sally J.; Chakrabarti,B.; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Leemans, Alexander; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2016)It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum ...
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Identification and validation of biomarkers for autism spectrum disorders
Loth, Eva; Spooren, Will; Ham, Lindsay M.; Isaac, Maria B.; Auriche-Benichou, Caroline; Banaschewski, Tobias; Baron-Cohen,Simon; Broich, Karl; Boelte, Sven; Bourgeron, Thomas; Charman, Tony; Collier, David; de Andres-Trelles, Fernando; Durston, Sarah; Ecker, Christine; Elferink, Andre; Haberkamp, Marion; Hemmings, Robert; Johnson, Mark H.; Jones, Emily J. H.; Khwaja, Omar S.; Lenton, Sabine; Mason, Luke; Mantua, Valentina; Meyer-Lindenberg, Andreas; Lombardo,Michael V.; O'Dwyer, Laurence; Okamoto, Koichi; Pandina, Gahan J.; Pani, Luca; Persico, Antonio M.; Simonoff, Emily; Tauscher-Wisniewski, Sitra; Llinares-Garcia, Jordi; Vamvakas, Spiros; Williams,Steven C. R.; Buitelaar, Jan K.; Murphy,Declan G. M. (2016)Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders, but effective medical treatments for the core symptoms of the disorder are still lacking. According to the Diagnostic and Statistical ...
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Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
Lai,Meng-Chuan; Lombardo,Michael V.; Chakrabarti,B.; Ecker,C.; Sadek,Susan A.; Wheelwright,Sally J.; Murphy,Declan G. M.; Suckling,John; Bullmore,Edward T.; Baron-Cohen,Simon; Bailey, Anthony J.; Bolton, P. F.; Carrington, S.; Daly,Eileen M.; Deoni,Sean C. L.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Pasco, Greg; Ruigrok,Amber N. V.; Spain,D.; Stewart, R.; Williams,Steven C. R. (2012)Individual differences in cognitive style can be characterized along two dimensions: 'systemizing' (S, the drive to analyze or build 'rule-based' systems) and 'empathizing' (E, the drive to identify another's mental state ...
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Neuroanatomy of individual differences in language in adult males with autism
Lai,Meng-Chuan; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Suckling,John; Bullmore,Edward T.; Happé,Francesca; Murphy,Declan G. M.; Baron-Cohen,Simon (2015)One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural ...
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The neuropsychology of male adults with high-functioning autism or asperger syndrome
Wilson, C. E.; Happé,Francesca; Wheelwright,Sally J.; Ecker,C.; Lombardo,Michael V.; Johnston,Patrick; Daly,Eileen M.; Murphy,Clodagh M.; Spain,D.; Lai,Meng-Chuan; Chakrabarti,B.; Sauter, Disa A.; Baron-Cohen,Simon; Murphy,Declan G. M. (2014)Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, ...
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Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us?
Cadman, T.; Spain,D.; Johnston,Patrick; Russell, A.; Mataix-Cols, D.; Craig, Michael C.; Deeley, Q.; Robertson, D. M.; Murphy,Clodagh M.; Gillan, N.; Wilson, C. E.; Mendez, M.; Ecker,C.; Daly,Eileen M.; Findon, J.; Glaser, K.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R.; Happé,Francesca; Murphy,Clodagh M. (2015)Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD ...
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On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis
Martinez-Murcia, Francisco; Lai,Meng-Chuan; Górriz, Juan Manuel; Ramirez, Javier; Young, Adam M. H.; Deoni,Sean C. L.; Ecker,C.; Lombardo,Michael V.; MRC AIMS Consortium; Baron-Cohen,Simon; Murphy,Declan G. M.; Bullmore,Edward T.; Suckling,John; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Catani, Marco; Chakrabarti,B.; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Spain,D.; Stewart, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2017)Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment ...
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Relationship between cortical gyrification, white matter connectivity, and autism spectrum disorder
Ecker,C.; Andrews, Derek Sayre; Dell’Acqua, Flavio; Daly,Eileen M.; Murphy,Clodagh M.; Catani, Marco; Schotten, Thiebaut De; Baron-Cohen,Simon; Lai,Meng-Chuan; Lombardo,Michael V.; Bullmore,Edward T.; Suckling,John; Williams,Steven C. R.; Jones, D. K.; Chiocchetti, A.; Murphy,Declan G. M. (2016)Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is accompanied by differences in gray matter neuroanatomy and white matter connectivity. However, it is unknown whether these differences are ...
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Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay
Balardin, J. B.; Sato, J. R.; Vieira, G.; Feng, Yue; Daly,Eileen M.; Murphy,Clodagh M.; Bailey, Anthony J.; Carrington, S.; Jezzard, Peter; Stewart, R.; Baron-Cohen,Simon; Bullmore,Edward T.; Chakrabarti,B.; Henty, Julian; Lai,Meng-Chuan; Lombardo,Michael V.; Pasco, Greg; Ruigrok,Amber N. V.; Sadek,Susan A.; Suckling,John; Wheelwright,Sally J.; Bolton, P. F.; Catani, Marco; Craig, Michael C.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Johnston,Patrick; Jones, D. K.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Spain,D.; Williams,Steven C. R.; Wilson, C. E.; Murphy,Clodagh M. (2015)Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the ...
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Sex differences in frontal lobe connectivity in adults with autism spectrum conditions
Zeestraten, E. A.; Gudbrandsen, Maria; Daly,Eileen M.; de Schotten, Michel Thiebaut; Catani, Marco; Dell’Acqua, Flavio; Lai,Meng-Chuan; Ruigrok,Amber N. V.; Lombardo,Michael V.; Chakrabarti,B.; Baron-Cohen,Simon; Ecker,C.; Murphy,Declan G. M.; Craig, Michael C. (2017)Autism spectrum conditions (ASC) are more prevalent in males than females. The biological basis of this difference remains unclear. It has been postulated that one of the primary causes of ASC is a partial disconnection ...
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A typically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay
Floris, Dorothea L.; Lai,Meng-Chuan; Auer, Tibor; Lombardo,Michael V.; Ecker,C.; Chakrabarti,B.; Wheelwright,Sally J.; Bullmore,Edward T.; Murphy,Declan G. M.; Baron-Cohen,Simon; Suckling,John (2016)In humans, both language and fine motor skills are associated with left-hemisphere specialization, whereas visuospatial skills are associated with right-hemisphere specialization. Individuals with autism spectrum conditions ...
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Unsupervised data-driven stratification of mentalizing heterogeneity in autism
Lombardo,Michael V.; Lai,Meng-Chuan; Auyeung, Bonnie; Holt, R. J.; Allison, Carrie; Smith, P.; Chakrabarti,B.; Ruigrok,Amber N. V.; Suckling,John; Bullmore,Edward T.; Ecker,C.; Craig, Michael C.; Murphy,Declan G. M.; Happé,Francesca; Baron-Cohen,Simon (2016)Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a ...
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White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder
Sundram, F.; Deeley, Q.; Sarkar, S.; Daly,Eileen M.; Latham, R.; Craig, Michael C.; Raczek, M.; Fahy, T.; Picchioni, M.; Barker, G. J.; Murphy,Declan G. M.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lai,Meng-Chuan; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2012)Antisocial personality disorder (ASPD) and psychopathy involve significant interpersonal and behavioural impairments. However, little is known about their underlying neurobiology and in particular, abnormalities in white ...
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White-matter relaxation time and myelin water fraction differences in young adults with autism
Deoni,Sean C. L.; Zinkstok, J. R.; Daly,Eileen M.; Ecker,C.; Williams,Steven C. R.; Murphy,Declan G. M.; Bailey, Anthony J.; Baron-Cohen,Simon; Bolton, P. F.; Bullmore,Edward T.; Carrington, S.; Chakrabarti,B.; Daly,Eileen M.; Deoni,Sean C. L.; Ecker,C.; Happé,Francesca; Henty, Julian; Jezzard, Peter; Johnston,Patrick; Jones, D. K.; Lombardo,Michael V.; Madden, A.; Mullins, D.; Murphy,Clodagh M.; Murphy,Declan G. M.; Pasco, Greg; Sadek,Susan A.; Spain,D.; Steward, R.; Suckling,John; Wheelwright,Sally J.; Williams,Steven C. R. (2015)Background. Increasing evidence suggests that autism is associated with abnormal white-matter (WM) anatomy and impaired brain 'connectivity'. While myelin plays a critical role in synchronized brain communication, its ...